01: rbc abnormal morph/inclusions

Question 1

1. What is a poikiocyte?

Answer 1

1. a word for general RBC abnormalities

Question 2

(spherocyte)

1. only in what animal?
2. from what?

Answer 2

1. dog
2. immune mediated dmg (zinc, IMHA)

Question 3

(schistocyte + keratocyte)

1. from what?
2. assoc w/?

Answer 3

1. physical dmg
2. DIC, hemangiosarcoma, vasculitis, iron def

Question 4

(eccentrocyte)

1. how does it look?
2. from what?
3. seen with what?

Answer 4

1. hgb on one side, clear on other
2. oxidative dmg
3. heinz bodies

Question 5

(ghost cells)

1. what are they?
2. from what?

Answer 5

1. empty RBC from lysis
2. artifact

intravascular hemolysis (IMHA, heinz body hemolysis)

Question 6

(acanthocyte)

1. what are they?
2. from what?

Answer 6

1. surface projections from altered lipid/cholesterol
2. splenic hemangiosarcoma, liver dz, renal dz

Question 7

(echinocyte)

1. look like?
2. from what?

Answer 7

1. regular spaced projections
2. artifact, electrolyte depeletion, renal dz

Question 8

(codocyte “target cell”)

1. what are they?
2. from what?

Answer 8

1. RBC w/ excess membrane
2. regen anemia, hepatic/renal dz

(limited significance)

Question 9

(heinz bodies)

1. what are they?
2. from what?

Answer 9

1. clumps of denatured hgb
2. oxidative dmg

Question 10

(basophilic stippling)

1. what are they?
2. from what?

Answer 10

1. aggregates of ribosomes
2. regen anemia, lead toxicity

Question 11

(howell-jolly bodies)

1. what are they?
2. from what?

Answer 11

1. nuclear remnant in RBC
2. regen anemia, suppressed splenic fx

Question 12

(nucleated RBCs)

1. normal to see in circ?
2. from what?

Answer 12

1. no!
2. dmg to marrow endothelium, sometimes in regen anemia