06 - Changes in selected liver dz

Question 1

(PSS)

1. will leakage/induced enzymes be ^?
2. what will be markedly elevated?
3. what will RBC look like?

Answer 1

1. no: little liver dmg and cholestasis

(ALP may be high if in young growing animals)

2. bile acids
3. microcytic anemia (due to Fe sequestration) with low iron conc

Question 2

(hepatic necrosis)

1. if focal?
2. in diffuse?

Answer 2

1. leakage enzymes may be normal or mildly elevated
2. elevations in both leakage and induced enzymes

Question 3

(hypoxia or mild toxic damage)

1. see elevations in what?
2. what may be mildly increased?

Answer 3

1. leakage enzymes mildly to moderately elevated

induced enzymes normal

2. bile acids

Question 4

(focal lesions)

1. leakage enzmyes?
2. induced enzymes?

Answer 4

1. normal to mildly ^
2. normal unless bile flow impaired

Question 5

(hepatic lipidosis)

1. leakage enzymes?
2. ALP? GGT?
3. serum bilirubin and bile acids?

Answer 5

1. increased in most
2. elevated in most, elevated in only a small number
3. both elevated

Question 6

(steroid hepatopathy)

1. most common in what animal?
2. leakage enzymes?
3. induced enzymes?

Answer 6

1. dogs
2. mild ^
3. marked ^

Question 7

(biliary disorders)

1. leakage enzymes?
2. induced enzymes?
3. what else are typically ^?

Answer 7

1. may be mildly ^ as a result of hepatocyte injury from cholestasis
2. markedly ^
3. bilirubin and bile acids

Question 8

(chronic liver dz)

1. leakage enzymes?
2. induced enzymes?
3. bilirubin?

Answer 8

1. may be ^, depending on the extent and rate of dz progression
2. usually mild/mod ^
3. normal to mild ^ in those w/ advanced dz

Question 9

(end stage liver dz)

1. occurs when?
2. leakage enzymes?
3. induced?
4. bilirubin and bile acid?
5. may have ^ ammonia, dec BUN, dec albumin, abnormal coagulation

Answer 9

1. when 60-80% of liver mass has been lost
2. may be normal/mildly ^ due to overall loss of liver mass
3. mod/marked increase
4. mod/marked increase