05 - Drug absorption & distribution Flashcards
ADME stands for…
Absorption, distribution, metabolism, excretion
Absorption is the tranfer of an…
Exogenous compound from the site of administration into the systemic circulation
In order to be absorbed, a drug will usually need to cross…
a) Blood-brain Barrier
b) Cell membranes
c) Nuclear envelope
b) Cell membranes
List 5 possible routes of administration…
Sublingually (under tongue), orally, topically (on or through the skin), eyes, rectum, intramuscular injection, intrathecal (spine), vaginal, rectal, inhalation…
Route of administration defines the speed at which the drug gets into…
Circulation
Dermal administration is ( faster / slower / the same speed ) when compared to oral administration
Slower (very slow)
The fastest route into circulation is…
Intravenous
Parenteral delivery
Intramuscular, intravenus or subcutaneous injection
The low pH in the stomach means many drugs will be ionised, thus…
Unable to cross the membrane
Enterocytes are…
Absorptive cells in the lining of the small intestine wall
First pass metabolism usually results in…
High loss
Rectal administration results in a large loss of dose, but is useful when the patient is…
Vomiting
Transdermal administration is good for drugs that are highly:
a) Water soluble
b) Lipophobic
c) Charged
d) Lipid soluble
d) Lipid soluble
Most drugs are:
a) weak acid
b) neutral pH
c) strong base
d) weak acid or base
d) weak acid or base
The biopharmaceutics classficiation system classifies drugs according to 4 levels based on (2)…
Permeability and solubility
