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Systemic Disease > 03. Derm II > Flashcards

03. Derm II Flashcards

1
Q

What is the typical presentation of Psoriasis?

A

Well demarcated salmon-pink plaques with silver scales on skin

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2
Q

Psoriasis is associated with which gene?

A

HLA B27

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3
Q

What is Auspitz sign, and in which condition is it found?

A

Pinpoint bleeding when scales are removed

Psoriasis

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4
Q

Psoriasis my be initiated or exacerbated by what type of glaucoma meds?

A

Beta-blockers

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5
Q

What are the “important” treatments for psoriasis?

A 
PUVA
Oral methotraxate
Cyclosporine
Anthralin
Topical Cortico-steroids
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6
Q

What are the “important” ocular findings associated with psoriasis?

A 
Symblepharon
KCS
Dellen
Fliamentary keratitis
Secondary cataract (Tx)
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7
Q

Psoriaritis arthritis is sero-negative/positive?

A

Sero-negative

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8
Q

Psoriaritic arthritis is found in increased prevalence with what genes?

A

HLA B27

HLA B17

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9
Q

Psoriaritic arthritis is associated with what ocular condition?

A

Uveitis

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10
Q

Rosacea is characterized by what signs?

A

Telangiectasia
Erythema
Papules
Pustules

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11
Q

What tissue hypertrophy is commonly found in rosacea?

A

Rhinophyma

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12
Q

What are the common ocular findings of rosacea?

A 
Dry eye
Blepharitis
Phlyctenules
Pannus
Iritis
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13
Q

In ocular rosacea, what causes phlyctenules or perilimbal infiltrates?

A

Staph hypersensitivity

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14
Q

What are the common Txs for rosacea?

A

Tetracycline
Doxycycline
Erythromycin

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15
Q

What Tx is contraindicated in rosacea?

A

Topical fluorinated corticosteroids

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16
Q

Of the three albinism syndromes, in which is bleeding/hemorrhage typically seen?

A

Hermansky-Pudlak

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17
Q

Of the three albinism syndromes, in which is immune dysfunction found?

A

Chediak-Higashi

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18
Q

Which of the three albinism syndromes may display immuno-deficiency?

A

Griscelli

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19
Q

What are the ocular findings in albinism?

A 
Iris TID
Photophobia
Nystagmus
Disposition to RD
Papilledema and infiltration with leukocytes in accelerated stage
Immune system dysfunction
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20
Q

What is incontinentia pigmenti?

A

Ectodermal dysplasia affecting the skin

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21
Q

What is the inheritance pattern of incotinentia pigmenti?

A

X-linked

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22
Q

The most significant findings of incotinentia pegmenti are retinal. What are they?

A

Abnormal blood vessels
RPE mottling
Foveal hypoplasia
RD

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23
Q

What type of inheritance is noted with nevus of OTA?

A

Sporadic inheritance

24
Q

Nevus of OTA involves the dermal distribution of what nerves?

25
A nevus of OTA can change in size and color with what events?
``` Age Trauma Puberty Menarche Menses Menopause Pregnancy ```
26
What are the iris signs of nevus of OTA?
Iris mamillations | TM affected, causing glaucoma
27
Nevus of OTA carries a higher risk of increased IOP, but it is unrelated to what?
Degree of angle pigmentation
28
What is the inheritance pattern of vitiligo?
Autosomal dominant
29
Vitiligo is hypothesized to have what MOA?
Autoimmune
30
What are the ocular findings associated with vitiligo?
``` Depigmentation of lid Poliosis Degpigmentation of uvea Pigment clumping in periphery Night blindness ```
31
What characterizes cicatricial pemphigoid?
Sub-epithelial bullae formation | Strictures of the skin and mucosa
32
Cicatricial pemphigoid affects which gender more frequently?
Female - starts in 30's
33
Cicatricial pemphigoid is what type of hypersensitivity?
Type II
34
What are the typical ocular findings of cicatricial pemphigoid?
``` Trichiasis Keratinization of the tarsal conj Entropion and lagophthalmos due to ankyloblepharon Aqueous deficient dry eye Mucin deficiency ```
35
What is used to treat cicatricial pemphigoid?
Pred acetate | Amniotic membrane
36
Epidermolysis bullosa is a deficiency of which collagen?
Collagen 7 in the dermis
37
Which pattern of inheritance of epidermolysis bullosa has the most significant eye findings?
Recessive
38
What characterizes epidermolysis bullosa?
Blister formation in response to relatively minor trauma
39
Mitten deformity is a systemic sign of what condition?
Epidermolysis bullosa
40
Epidermolysis bullosa shows an increased incidence of what cancer?
Squamous cell carcinoma
41
What are the common corneal findings of epidermolysis bullosa?
RCE Pannus Corneal scarring Exposure keratopathy
42
What is erythema multiforme?
Acute, inflammatory vesiculo-bullous reaction of the skin
43
What type of reaction is erythema multiforme>
Type IV
44
Erythema multiforme is associated with which gene?
HLA B12
45
What is the typical reason for the occurrence of erythema multiforme?
Drug/inciting agent | -sulphonamides, contraceptives, HSV, histo, epstein-barr
46
SJS is a reaction to what?
Drug
47
What is the typical prodrome of SJS?
Fever Malaise Sore throat Arthralgia
48
SJS presents with a severe erythematous maculo-papular rash that is atypical in what way?
Not itchy
49
Which is more severe, SJS or TEN?
TEN (Toxic epidermal necrolysis)
50
When does SJS become TEN?
>30% of body area
51
What viruses may cause SJS/TEN?
Strep HSV Mycoplasma pneumoniae
52
What drugs may induce SJS/TEN?
PCN Sulfa NSAIDs Anticonvulsants
53
Pemphigus vulgaris is which kind of disease?
Autoimmune
54
What type of reaction is pemphigus vulgaris?
Type II
55
Pemphigus vulgaris presents with a conjunctivitis that is:
Non-scarring

Systemic Disease (12 decks)

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