006 Flashcards
All the following characteristics are common to organspecific and organ-nonspecific disorders except:
a. Autoantibody tests are of diagnostic value.
b. Antibodies may appear in each of the main immunoglobulin classes.
c. Antigens are available to lymphoid system in low concentrations.
d. Circulatory autoantibodies react with normal body constituents.
c. Antigens are available to lymphoid system in low concentrations
Antibody expression in the development of autoimmunity is regulated by all the following factors except:
a. Genetic predisposition
b. Increasing age
c. Environmental factors (e.g., ultraviolet [UV] radiation)
d. Active infectious disease
d. Active infectious disease
The mechanism responsible for autoimmune disorder is:
a. Circulating immune complexes
b. Antigen excess
c. Antibody excess
d. Antigen deficiency
a. Circulating immune complexes
One of the mechanisms believed to induce self-tolerance is:
a. Induction of responsiveness in immunocompetent cells
b. Elimination of clone programmed to react with antigen
c. Decreased suppressor cell activity
d. Stimulation of clones of immunocompetent cells
b. Elimination of clone programmed to react with antigen
- _______ Acetylcholine receptor–blocking antibodies
- _______ Anticardiolipin antibody
- ___ ___ Anti-DNA antibodies
- _______ Anti–glomerular basement membrane antibodies
a. Helpful in monitoring Addison’s disease
b. Found in one third of patients with myasthenia gravis
c. Useful in monitoring the activity and exacerbations of SLE
d. Suggestive of Goodpasture’s disease
e. Present in SLE and associated with arterial and venous thrombosis
B
E
C
D
- _______ Antinuclear ribonucleoprotein
- _______ Anti-Scl
- _______ Anti-Sm
- _______ Anti–smooth muscle
a. Antibody to basic nonhistone nuclear protein, diagnostic of systemic sclerosis
b. Present in bullous pemphigoid
c. Presence of antibody confirms diagnosis of SLE
d. Seen in viral disorders
e. Characteristic of mixed connective tissue disease
E
A
C
D
- _______ Anti SS-A
- _______ Histone-reactive antinuclear antibody
- _______ PM-I antibody
a. Detectable in patients with myasthenia gravis
b. Demonstrable in Sjögren’s syndrome—sicca complex
c. Highly suggestive of drug-induced lupus erythematosus
d. Found in one third of patients with uncomplicated polymyositis and some patients with dermatomyositis
e. Found in most patients with polymyositis
B
C
E
The term autoimmune disorder is used when:
a. Demonstrable immunoglobulins display specificity for self antigens.
b. Cytotoxic T cells display specificity for self antigens.
c. Cytotoxic T cells contribute to the pathogenesis of the disease.
d. All of the above
d. All of the above
True or False
The presence of autoantibodies are only associated with autoimmune disease.
False
True or False
In organ-specific disorders, antigens are only available to the lymphoid system in low concentrations.
True
True or False
There is a familial tendency to develop organspecific disorders.
True
True or False
In organ-specific disorders, lesions are caused by deposition of antigen-antibody complexes.
False
True or False
In organ-specific disorders, there is a tendency to develop cancer.
True
Self-recognition (tolerance) is induced by:
a. Burnet’s clonal selection theory
b. Elimination of the small clone of immunocompetent cells programmed to react with the antigen
c. Induction of unresponsiveness in the immunocompetent cells through excessive antigen binding
d. All of the above
d. All of the above
- _______ Acetylcholine receptor binding antibody (AChR)
- _______ Anticentromere antibody
- _______ Antiintrinsic factor antibody
- _______ Antimitochondrial antibody
a. Strongly suggestive, in a high titer, of primary biliary binding antibody cirrhosis
b. Useful in the diagnosis of myasthenia gravis
c. Demonstrated in most patients with CREST syndrome
d. Found in 60% of patients with pernicious anemia
B
C
D
A
- _______ Antimyelin antibody
- _______ Antimyocardial antibody
- _______ Cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA)
- _______ Antinuclear antibody (ANA)
a. Associated with multiple myeloma
b. Marker for Wegener’s granulomatosis
c. Characteristic of untreated systemic lupus erythematosus
d. Diagnostic of Dressler’s syndrome or rheumatic fever
A
D
B
C
The immunologic manifestations of multiple sclerosis include all the following except:
a. Antimyelin antibodies
b. An oligoclonal increase in CSF immunoglobulin
c. In vitro antibody-mediated immunity
d. An increase in certain HLA and Ia antigens
c. In vitro antibody-mediated immunity
Most immunologically mediated renal diseases fall into one of the following categories, except for:
a. Association with circulating immune complexes
b. Association with circulating antigen
c. Association with anti–glomerular basement membrane antibody
d. Membranoproliferative glomerulonephritis
b. Association with circulating antigen
Polymyositis and dermatomyositis are the most common expressions of:
a. Rheumatoid heart disease
b. Skeletal muscle disorders
c. Rheumatoid arthritis
d. Either a or b
b. Skeletal muscle disorders
Indicate whether each of the following statements is true (A) or false (B) regarding the epidemiology of autoimmune pancreatitis.
38. ______ It is more common in women than men.
39. ______ Most patients are younger than 50 years at diagnosis.
40. ______ The number of reported cases has been decreasing over the last decade.
False
False
False
The immunologic abnormality associated with autoimmune pancreatitis in the Japanese population is:
a. Autoantibodies against carbonic anhydrase
b. HLA haplotype
c. Hypogammaglobulinemia
d. Elevated serum IgE levels
b. HLA haplotype
