00 F1 Endo Flashcards
HCO3- normal values
24-30
Hypophophataemia
Modest v severe
Range and tx
Modest : 0.4-0.75
— Sandophos TT TDS
Severe :
Hypophosphataemia
Sx
ATP and CNS
Myopathy
Seizures
Paraesthesia
Equivalent doses steroids
Dex: 2
Pred: 20
Hydrocortisone: 100
Consider addisons if Morning cortisol in hospital under x
Under 400
Sick days on addisons
Double steroid dose
Hypoglycaemia
Severity levels
Hypoglycaemia
Hyponatraemia severity
Mild 130-135
Moderate 120-130
Severe
Classify hyponatraemia
Volume status
And
Urinary sodium : inappropriate? Addisons, diuretic, renal ds, hypothyroid, siADH
? Pseudo hyponatraemia
Pseudo hyponatraemia
Glucose
Lipid
Para protein
Signs fluid status
CRT Skin turgor BP - lying standing JVP Mucus membranes - thirst HS Edema / ascites
Urinary sodium in
Hyponatraemia
Appropriate 20
pCO2 normal values
4.5-6 kpa
Tx addisonian crises
100mg hydrocortisone
Low TSH, normal T4
Sub clinical thyrotoxicosis
Excessive thyroxine replacement
Low T4, low/normal TSH
Sick euthyroid
- starvation, severe illness
MEN1
PPP
Parathyroid
Pancreas
Pituitary
MEN2
PTP
Parathyroid
Thyroid
Phaeochromocytoma
B + marfinoid
Contents cavernous sinus
CN 3-6
V ophthalmic division only
Internal carotid artery
Causes Cushing syndrome
Steroids
Pituitary adenoma
Ectopic ACTH
Adrenal Ca
Dex suppression outcomes
Full suppression - physiological
Some - pituitary
No - ectopic ACTH or adrenal Ca
Causes addisons ds
Autoimmune
Malignancy
TB
Infarction - post meningitis
DM complications
Microvascular - eye, kidney, nerves Macro - IHD, CVA, PVD Infx Skin and MSK
DM neuropathy Sx
Pain Postural hypotension Gastro paresis Diarrhoea, constipation Incontinence x2 Impotence
DM amyotrophy Sx
Painful weakness
Wasting quadriceps
Tx addisonian crises
100mg hydrocortisone
Low TSH, normal T4
Sub clinical thyrotoxicosis
Excessive thyroxine replacement
Low T4, low/normal TSH
Sick euthyroid
- starvation, severe illness
MEN1
PPP
Parathyroid
Pancreas
Pituitary
MEN2
PTP
Parathyroid
Thyroid
Phaeochromocytoma
B + marfinoid
Contents cavernous sinus
CN 3-6
V ophthalmic division only
Internal carotid artery
Causes Cushing syndrome
Steroids
Pituitary adenoma
Ectopic ACTH
Adrenal Ca
Dex suppression outcomes
Full suppression - physiological
Some - pituitary
No - ectopic ACTH or adrenal Ca
Causes addisons ds
Autoimmune
Malignancy
TB
Infarction - post meningitis
DM complications
Microvascular - eye, kidney, nerves Macro - IHD, CVA, PVD Infx Skin and MSK
DM neuropathy Sx
Pain Postural hypotension Gastro paresis Diarrhoea, constipation Incontinence x2 Impotence
DM amyotrophy Sx
Painful weakness
Wasting quadriceps
Unexplained weight loss
Good appetite
- DM, thyrotoxicosis, malabsorption (coeliac)
Poor appetite
- ca, chronic ds, anaemia, psych
Causes Obesity
Overeating
Cushings
Hypothyroid
Thready pulse
Rapid low volume
Dehydration
Causes bradycardia
B blocker
Heart block
Hypothyroid
Raised ICP
Causes of Bigeminy or trigeminy
Digoxin toxicity
Pulsus alternans
LVF
SVT
Endocrine causes HTN
Cushings
Conns
Phaechromocytoma
Acromegaly
Types shock
Hypovolaemia
Cardiogenic
Septic
Neurogenic
Causes of Raised JVP
Overload R HF Arrhythmia Pericardial ds Jugular vein ob
Gallop rhythm
S3+S4
Severe HF
Severity HF : extra HS
S3 - HF
S3+S4 - severe HF
Comp infx endocarditis
Embolic
Mycotic aneurysm
Rupture of valve causing HF
Stop statin if ALT >
> 3x Upper limit
~150