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L2 > Zoonoses > Flashcards

Zoonoses Flashcards

1
Q

Yersinia pestis virulence factors

A

PsaA, YadA, YpkA, Yop H, M

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2
Q

PsaA

A

pilus adhesin, produced maximally at pH 6 (in phagolysosome); chromosomally encoded, 37 degrees

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3
Q

YadA

A

plasmid encoded, 37 degrees; host receptors = beta 1 integrins, laminin, fibronectin

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4
Q

Yops

A

plasmid encoded, antiphagocytic

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5
Q

YpkA

A

ser/thr kinase activity

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6
Q

YopH

A

tyrosine phosphatase activity, inhibits intracellular signaling

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7
Q

YopM

A

indirectly affects signaling by preventing platelets from releasing cytokines

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8
Q

YopE

A

destroys actin monofilaments

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9
Q

LcrV

A

essential for full expression of Yops

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10
Q

fraction L Fra1 protein capsule

A

antiphagocytic and activates complement

plasmid-encoded and expressed mostly at 37 degrees

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11
Q

Pla (plasminogen activator)

A

degrades C3b and C5a
degrades some Yops
dissolves fibrin clots

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L2 (15 decks)

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