Paraneoplastic Syndromes

Question 1

cushing syndrome

Answer 1

ACTH - SCC of lung, pancreatic carcinoma, neural tumors

Question 2

SIADH

Answer 2

ADH (or ANF)

SCC of lung and intracranial neoplasms

Question 3

hypercalcemia

Answer 3

PTH-RP and TGF-alpha, TNF, IL-1
SCC of lung, breast carcinoma
renal carcinoma, Adult T Cell Leukemia/Lymphoma

Question 4

hypoglycemia

Answer 4

insulin

ovarian carcinoma, fibrosarcoma

Question 5

carcinoid syndrome

Answer 5

serotonin & bradykinin

pancreatic carcinoma and bronchial carcinoma

Question 6

polycythemia

Answer 6

erythropoietin (made by JG cells)

renal cell carcinoma, gastric carcinoma, cerebellar hemangioma, hepatocellular carcinoma

Question 7

myasthenia

Answer 7

bronchogenic carcinoma

Question 8

neuropathies

Answer 8

breast carcinoma, small cell carcinoma

Question 9

acanthosis nigricans (black splotchy plaques that occur in the axillary folds of skin)

Answer 9

gastric carcinoma
lung carcinoma
uterine carcinoma

Question 10

Trousseau’s sign - migratory deep vein thrombosis

Answer 10

tumor products – mucins activate clotting
pancreatic cancer
GI tract, lung cancer

Question 11

clubbing of fingers

Answer 11

lung cancer

Question 12

fever of unknown origin, night sweats

Answer 12

lymphomas (Hodgkin’s)
renal carcinoma
osteogenic sarcoma

Question 13

peripheral neuropathy, dermatomyositis

Answer 13

small cell carcinoma of lung