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L2 > Stuff > Flashcards

Stuff Flashcards

1
Q

EGF and TGF alpha

A

made by keratinocytes, macrophages, inflammatory cells
mitogenic for hepatocytes, fibroblasts, epithelial cells
HER2 overexpressed

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2
Q

HGF

A

made by fibroblasts, CT cells, non-parenchymal liver cells
mitogenic for hepatocytes and epithelial cells
receptor MET overexpressed in tumors (renal & thyroid papillary carcinomas)

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3
Q

PDGF

A

made by macrophages, endothelial cells, SM cells, tumor cells
migration of fibroblasts, SM, monocytes to areas of wound healing

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4
Q

VEGF

A

vascular dilation, increased vascular permeability stimulated by hypoxia

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5
Q

Platelet dense granules?

A 
histamine
serotonin
epinephrine
Ca
ADP, ATP
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6
Q

Platelet alpha granules?

A

fibrinogen, fibronectin, factors 5, 8, platelet factor 4 , PGDF, TGF-Beta

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7
Q

CML

A

t(9:22) ABL

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8
Q

Burkitt’s Lymphoma

A

t(8:14) c-MYC

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9
Q

Rb

A

-13

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10
Q

Wilms’ Tumor

A

-11

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11
Q

Neuroblastoma gene amplification

A

N-myc

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12
Q

BRAF

A

malignant melanoma

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13
Q

Epithelial Markers

A

CEA, keratin, EMA

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14
Q

Mesenchymal Markers

A

vimentin, desmin

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15
Q

Nerve, Neuroendocrine Markers

A

NSE, chromogranins

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16
Q

Prostate Cancer

A

PSA, PAP

17
Q

Lymphomas

A

LCA, B and T cell markers

18
Q

Endocrine tumors

A

various hormones

19
Q

CEA

A

colorectal, pancreatic, liver, gastric cancers

20
Q

AFP

A

liver and germ cell tumor of testis

21
Q

HCG

A

chorionic carcinoma, germ cell tumors

22
Q

GFAP

A

neuroglia

23
Q

S-100

A

breast

24
Q

CA 19-9

A

colon, pancreas

25
Q

CA 15-3

A

breast

26
Q

CA-125

A

ovarian

27
Q

Metastasis to bone?

A

prostate, lung, breast, thyroid, kidney

28
Q

metasisis to brain?

A

lung, breast, kidney

29
Q

which invade veins?

A

RCC, hepatocellular carcinoma

30
Q

myasthenia

A

bronchogenic carcinoma

31
Q

neuropathies

A

breast carcinoma, small cell carcinoma

32
Q

Bradykinin?

A

vasodilation, increased vascular perm, pain

33
Q

Kallikrein

A

increased chemotaxis, plasmin generation, increae inflammation

34
Q

Thrombin

A

thrombin binds to protease-activated receptors
increases inflammatory response:
1. increase endothelial adhesion molecules
2. make cytokines - PAF, NO
3. make PGs

35
Q

plasmin

A

increases inflammatory response by
cleaving c3
activating hageman factor

36
Q

endothelial cells

A

endothelin: prolonged vasoconstriction

NO, PGI2: inhibits platelet aggregation, vasodilation

L2 (15 decks)

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