Zollinger-Ellison syndrome (ZES) Flashcards
1
Q
Zollinger-Ellison syndrome is condition characterised by excessive levels of what?
A
Gastrin secretion
2
Q
What is normally the cause of the excessive gastrin secretion?
A
Gastrin secreting tumour usually in the pancreas or duodenum
3
Q
What condition is ZES commonly associated with?
A
Multiple endocrine neoplasia type 1
4
Q
MEN type 1 is associated with abnormalities of which 3 glands?
A
- Pancreas
- Pituitary
- Parathyroid
5
Q
Name 2 features of ZES
A
- Multiple gastroduodenal ulcers that don’t respond to PPIs
- Diarrhoea
- Malabsorption
- Abdominal pain
6
Q
1) What is the best screening test?
2) What is the diagnostic test?
3) What is the best imaging modality?
A
1) Fasting gastrin levels
2) Secretin stimulation test
3) Somatostatin receptor scintigraphy
7
Q
What electrolyte abnormality is most commonly associated with MEN type 1?
A
Hypercalcaemia
8
Q
Name a tumour associated with MEN type IIa and IIb
A
- Pheochromocytoma
- Medullary thyroid tumour
