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Adv Nutrition Sci Test 1 > Zinc And Copper > Flashcards

Zinc And Copper Flashcards

1
Q

What happens if zinc and copper are not needed

A

Get excreted in feces when intestinal cells slough off

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2
Q

What protein binds to iron in the intestine

A

Ferritin

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3
Q

Zinc is a cofactor for what 3 major enzymes

A

Carbonic anhydrase

Alpha aminolevulinic acid dehydratase

Polyglutamate hydrolase

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4
Q

Role of carbonic anhydrase

A

Combines CO2 and H2O

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5
Q

Function of alpha aminolevulinic acid dehydratase

A

Heme synthesis

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6
Q

Polyglutamate hydrolase

A

Digestion of polyglutamates from folate

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7
Q

What is a main function of zinc in relation to DNA

A

Helps transcription factors interact better with DNA

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8
Q

What is primary transport for copper

A

Ceruloplasmin

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9
Q

Ceruloplasmin is also important in

A

Iron metabolism

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10
Q

ATP7B role

A

Helps copper attach to Ceruloplasmin in liver for transport

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11
Q

ATP7A role

A

Helps copper attach to Ceruloplasmin in intestine for transport

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12
Q

Primary form of circulating Cu is

A

Ceruloplasmin

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13
Q

What are secondary proteins for transport of circulating copper

A

Albumin and alpha-2 macroglobulin

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14
Q

Ceruloplasmin brings copper to other tissues after it binds to its receptor

A

K

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15
Q

Copper deficiency can impair transport of what mineral

A

Iron

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16
Q

Ceruloplasmin has what major function with iron

A

Can oxidize it to prepare it for transport

17
Q

What are 3 enzymes that require copper

A

Ceruloplasmin

Cytochrome c oxidase

Amine oxidases

18
Q

Two common copper related diseases are

A

Menkes disease

Wilson disease

19
Q

Menkes disease characteristics

A

Defect in ATP7A

Impairs transport from intestine

Causes neurological and vascular problems

Life expectancy is a few years

20
Q

Wilson disease characteristics

A

Defect in ATP7B

Impaired transport from liver

Causes cirrhosis, anemia, skeletal defects, neutropenia

Life expectancy is normal when treated

21
Q

How is zinc and copper stored short term in the intestine

A

They bind to metallothionein

Copper binds more tightly

Adv Nutrition Sci Test 1 (14 decks)

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