Niacin Flashcards
1
Q
What are the 4 mechanisms of action of niacin
A
Inhibition of lipolysis in adipose tissue
Decreased VLDL synthesis, and this LDL production
Inhibition of diacylglycerol acyltransferase
Increase HDL levels
2
Q
6 Symptoms of toxicity of nicotenic acid
A
Vasodilatory effects - flushing GI symptoms Liver injury Hyperuricemia or gout Glucose intolerance Blurred vision
3
Q
What is tolerable upper limit of niacin and what can a typical nicotenic acid dosage go up to
A
35 mg/day
6 g/day
4
Q
What does a niacin deficiency typically cause?
A
Pellagra
5
Q
What are beginning stage of pellagra
A
Poor digestion, absorption, lethargy, anorexia
6
Q
What are the 4 D’s of niacin deficiency
A
Dermatitis
Dementia
Diarrhea
Death
7
Q
What vitamin does pellagra affect
A
B6
8
Q
What is a hallmark symptom of niacin deficiency
A
Area of dry skin around the neck called kazals collar
9
Q
What can nicotenic be prescribed to treat?
A
Hyercholesterolemia
