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Adv Nutrition Sci Test 1 > Iron > Flashcards

Iron Flashcards

1
Q

This protein is in the brush border and transports ferrous iron into the cell (not ferric iron)

A

DMT1

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2
Q

This protein is in the basolateral membrane and it transports ferrous iron out of the intestinal cell

A

Ferroportin

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3
Q

This protein is in the basolateral membrane and blood and it oxidizes iron to ferric iron (Fe3+)

A

Hephaestin

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4
Q

This protein is in the blood and transports oxidized iron

A

Transferrin

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5
Q

Storage protein for iron (usually present in higher amounts under high iron)

A

Hemosidirin

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6
Q

This protein is present in the enterocyte and it binds up to 3 iron atoms to prevent oxidative damage and transports iron inside cells

A

PCBP1

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7
Q

This protein is synthesized in the liver and it binds to Ferroportin and degrades it. Present under high levels of iron and recycles it

A

Hepcidin

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8
Q

These proteins is in the blood and it binds to heme and hemoglobin and brings it to the liver to release iron and recycle it

A

Haptoglobin and hemopexin

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9
Q

This protein is in the various tissues and plasma and it stores iron as ferric oxyhydroxide

A

Ferritin

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10
Q

What is the main regulator of iron transport outside of the cell

A

Hepcidin

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11
Q

Under high iron condition what is the effect on IRE-BP

How many iron are bound to it?

A

It goes to TCA cycle to help convert citrate to isocitrate

4

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12
Q

Under low iron condition what happens to IRE-BP

How many iron are bound to it?

A

Goes to nucleus of cells and binds to specific mRNA which decrease levels of ferritin and increase transferrin

3

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13
Q

What are the 3 general categories of enzymes that require iron as a cofactor

A

Cytochromes

Monooxygenases

Dioxygenases

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14
Q

What enzyme contains iron that is important in thyroid hormone synthesis

A

Thyroperoxidase

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15
Q

What are the stages of iron deficiency

A

Decrease in iron stores

Decrease in circulation iron

Free portoporphyrin concentration in RBC and transferrin receptors rise

Anemia

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16
Q

How is stage 1 a decrease in iron stores assessed

A

By measuring ferritin

17
Q

How is stage 2 a decrease in circulation iron assessed

A

Transferrin saturation decreases to less than 16%

18
Q

How is stage 4 deficiency anemia assessed

A

Hemoglobin drops below 12-13 g/dl
Hematocrit drops below 40%
Microcytic, hypochromic
MCV and MCH are lower than normal

19
Q

How do you differentiate between folate and B12 deficiency anemia and iron anemia

A

MCV and MCH are lower than normal

20
Q

What stages occur early in iron deficiency

A

Stage 1

21
Q

What stages or or later in iron deficiency

A

Anemia

22
Q

This protein is in the brush border of the duodenum and absorbs heme into the enterocyte

A

Hcp1

Adv Nutrition Sci Test 1 (14 decks)

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