Vitamin K

Question 1

Function of gamma glutamyl carboxylase

Answer 1

Carboxylates glutamic acid to form carboxyglutamic acid residues (GLA)

Question 2

Vitamin k travels through the blood in what form

Answer 2

Oxidized form

Vitamin k quinone

Question 3

What must happen to vitamin K to function with gamma glutamyl carboxylase

Answer 3

Must be reduced

Question 4

What is the importance of GLA proteins

Answer 4

Blood clotting and bone mineralization

Question 5

For Glutamic acid residues to function what must happen first

Answer 5

All glutamic residues must be carboxylated

Question 6

Carboxylation of GLA serves to bind want and where?

Answer 6

Calcium to the site of injury

Question 7

What is the final product of the coagulation cascade

Answer 7

Fibrin

Question 8

What clotting factors form the fibrin clot

Answer 8

Prothrombin (factor II), VII, IX and X

Question 9

What proteins are inhibitors of pro coagulant system

Answer 9

Proteins C, S, and Z

Question 10

Fibrinogen is converted to

Answer 10

Fibrin (insoluble fiber network)

Question 11

4 Steps of a blood clot

Answer 11

Cascade events activates clotting factors

Fibrinogen ——> fibrin

Fibrin congregate and become a polymer which interacts with fibrin stabilizing factor

Result is insoluble clot to inhibit bleeding

Question 12

Know slide 24 In module 2 review well

Answer 12

K

Question 13

Vitamin k is needed for what enzyme

Answer 13

Gamma glutamyl carboxylase

Question 14

What are the 3 different states vitamin k can exist in

Answer 14

Dihydroquinone (most reduced form)

Vitamin k 2,3 epoxide (most oxidized form)

Vitamin k quinone (most stable form, transported in blood)

Question 15

Dihydroquinone is needed for what to function

Answer 15

Gamma-glutamyl carboxylase

Question 16

What is warfarins effect on vitamin k

Answer 16

Prevents it from being reduced

Question 17

Know what foods potentiate and inhibit warfarin

Answer 17

K