Zinc

Question 1

Is zincs availability affected by heat? (aka cooking)

Answer 1

Yes

Question 2

Who is more likely to be deficient in zinc?

Answer 2

elderly and vegetarians

Question 3

what protein is stored zinc usually bound to?

Answer 3

thionein as metallothionein

Question 4

T/F zinc can deactivate reactive oxygen species

Answer 4

True

Question 5

How does zinc transport from lumen to cell?

Answer 5

ZIP4 transporter

Question 6

what does ZIP4 stand for?

Answer 6

Zrt and Irt-like protein 4

Question 7

T/F zinc can passively diffuse into the cell

Answer 7

True

Question 8

T/F zinc can be absorbed via paracellular absorption with high intake

Answer 8

True

Question 9

How does zinc transport out of the cell to the plasma?

Answer 9

ZnT1

Question 10

what does zinc bind to after its transported out of the cell to the plasma?

Answer 10

albumin

Question 11

which transporter transports zinc from both the cell to lumen and lumen to cell?

Answer 11

ZnT5B

Question 12

how does zinc transport into cell from the plasma?

Answer 12

ZIP5

Question 13

T/F regardless of transport, (paracellular, transcellular) zinc will bind to albumin in the plasma

Answer 13

True

Question 14

which of these enhances absorption of zinc? (multiple answers)

a. Polycyclic acid
b. Citric acid
c. Picolinic acid
d. Glucagon
e. Prostaglandins
f. amino acids (cysteine & histamine)
g. amino acids (lysine & methionine)
h. low zinc status

Answer 14

b,c,e,f,h

Question 15

T/F cysteine/histamine are good chelators of zinc

Answer 15

True

Question 16

which of these inhibits absorption of zinc? (multiple answers)

a. phytates
b. phyrates
c. polyphenols
d. sulfuric acid
e. oxalic acid
f. iron, calcium, and copper
g. NSAIDS
h. aspirin

Answer 16

a,c,e,f,h

Question 17

how do phytates inhibit zinc?

Answer 17

when they bind to zinc they make it non bioavailable

Question 18

What is the name of the complex where zinc is stored in the cell?

Answer 18

Metallothionein

Question 19

What is CRIP?

a. an external protein that actively transports zinc into the cell
b. an internal cell protein that moves zinc around via intracellular transport
c. an internal cell protein that intracellularly transports zinc to storage
d. an external protein that binds to zinc making it more polar

Answer 19

b

Question 20

name three ligands/chelates that bind to zinc in the small intestine

Answer 20

oxalate
phytate
tannin

Question 21

T/F once a ligand/chelate binds to zinc, it is either transported into the cell by ZIP4 or excreted out

Answer 21

True

Question 22

Which of these transporters transport zinc in the blood? (multiple answers)

a. transferrin
b. beta-1 metalloglobulin
c. immunoglobulin G
d. alpha-2 macroglobulin
e. zinc hemotransferase

Answer 22

a,c,d

Question 23

which organ is zinc primarily located in?

Answer 23

liver

Question 24

which vitamin increases zinc absorption?

a. vitamin B1
b. Vitamin C
c. Vitamin A
d. Vitamin D

Answer 24

c. Vitamin A

Question 25

Which nutrient decreases zinc absorption?

a. Calcium
b. Potassium
c. Sodium
d. Titanium

Answer 25

a

Question 26

Does copper decrease zinc absorption?

Answer 26

Yes

Question 27

How is zinc mainly excreted?

Answer 27

GI tract

Question 28

What disease is caused by a mutation in ZIP4 which causes poor zinc absorption?

Answer 28

Acrodermatitis enteropathica

Question 29

How do you treat Acrodermatitis enteropathica? How does this treatment work?

Answer 29

highly toxic doses of zinc: allows zinc to be absorbed via paracellular diffusion

Question 30

whats the RDA for men/women?

Answer 30

men: 11mg women: 8mg