Ziekteleer (Rudi) Flashcards
osteoporosis
- Caused by excessive bone loss over time, leading to brittle, easily broken bones.
- Usually starts showing around age 35.
- Caused by an imbalance between the rates of bone breakdown by osteoclasts and new bone formation by
osteoblasts.
Sprains
stretched or torn ligaments
bursitis and tendinitis
The inflammation of the bursae or tendons
Arthritis
A general term for joint inflammation.
osteoarthritis
degenerative condition in which the cartilage covering the ends of the bones wear out – causing more friction which eventually leads to an inflammation.
repetitive stress syndrome (carpal tunnel syndrome)
= performing the same task over and over
- a condition due to repetitive typing on a computer keyboard
- overuse produces swelilng and inflammation of the tendons, causing them to press against the nerve supplying the hand
Myasthenia gravis
› The body’s immune system attacks and destroys acetylcholine receptors on the cell membrane of muscle cells.
› Affected muscles only respond weakly to nerve impulses or don’t respond at all.
› Most commonly impaired are the eye muscles -> double vision and drooping eyelids.
› Medication that facilitates the transmission of nerve impulses can help people with this condition.
Muscular dystrophy
› Genetic disease: Duchenne muscular dystrophy – single defective gene results in the lack of a particular muscle cell protein.
› Normal gene produces dystrophin (protein) that is part of the muscle cell membrane – function is to limit the inflow of calcium into
muscle cells.
› Modified dystrophin protein enables leakage of Calcium into cells – resulting in loss of muscle fibres and muscle wasting.
› Much of the muscle mass is replaced with connective tissue.
› Life expectancy = 30 years
tetanus
› Infection of deep wound by bacteria Clostridium tetani.
› The bacteria produce tetanus toxin, which causes muscles to contract forcefully.
› Death due to respiratory failure and preventable by tetanus vaccine.
muscle cramps
often caused by ion imbalances
pulled muscles
result from overstretching of a muscle and the fibres tear apart
fasciitis
› Inflammation of fascia (connective tissue)
› Usually caused by straining or tearing the sole of foot (plantar fasciitis).
diabetes mellitus
» Disorder of blood sugar regulation.
- Inability to get glucose into cells where it can be used, results in high blood sugar levels.
- Glucose and excess water appear in the urine.
» Abnormal metabolism of carbohydrates, proteins, and lipids causes most of the complications.
TYPE I diabetes
» Pancreas does not produce enough insulin – autoimmune destruction of beta cells.
» Genetic component and/or environmental trigger – onset during childhood or adolescence
TYPE II diabetes
» Characterized by insulin resistance: cells fail to respond appropriately to insulin.
» Lifestyle factors play a role in onset – onset mostly in adults over 40.
hypothyroidism
underactive thyroid
* with children - cretinism
* with adults - myxedema
cretinism
=slowed growth, altered brain development, delayed puberty
myxedema
edema, lethargy, weight gain, low BMR
hyperthyroidism
overactive thyroid