inflammatory bowel disease Flashcards
inflammation ….. infection
IS NOT
What are the two major forms of IBD
- Crohn’s disease
- Ulcerative colitis
epidemiology of IBD
o Peak between the ages of 15-30 and second peak between the ages of 60-80.
oMore frequent in“rich” countries/places such as north America, Scandinavia, andEurope.
Where does UC begin
Colon and rectum
Where does CD begin
Any part of the GI tract
describe the development of UC
Continuous pattern of inflammation
describe the development of CD
Skips lesions
describe the onset of UC
Acute (sudden/rapid) onset
describe the onset of CD
Gradual onset
What happens within patients with UC
»Ulcers, ulcerations, (pseudo)polyps, bulges in mucosa
»Normal architecture damaged
»Microbiome affected.
» BLOOD IN STOOL
»Can cause colon cancer
What happens within patients with CD
» Entire intestinal wall affected.
» Granulomas (inflammations)
» Thicker wall, smaller lumen
» Cobble stones
» Perforations – stool leaks into abdominal cavity
What are the symptoms of UC
» Rectal bleeding
» Having to go to the toilet very often
» Loose stools
» Abdominal pain on the lower left side
»Tenesmus: urge to defecate
» Blood in stool
WHat are the symptoms of CD
» Chronic and nocturnal diarhhea OR constipated
» Pain in lower right abdomen
» Weight loss
» Mild fever
» Increases in severity with age = progressive disease
» absecces and fistulae
What are the extra intestinal symptoms of UC
»Joint pain
»Canker sore(aften) in mouth
»Spinal deformation due to inflammation
»Slow healing wounds
»Erythema nodosum
»Eye bleeding
WHat are the extra-intestinal symptoms of CD
» Inflammated joints
» Same as ulcerative colitis
» Kidney problems
» Galstones
» Liver problems