Z-drugs

Question 1

List three types of Z-drugs.

Answer 1

Zolpidem
Zopiclone
Zalepon

Question 2

What are Z-drugs?

Answer 2

Prescription drugs used to treat insomnia/

Question 3

What is an ideal drug to treat insomnia?

Answer 3

Hypnotic during nighttime without causing residual sleepiness during the daytime.

Question 4

Why are z-drugs considered ideal hypnotic drugs?

Answer 4

Rapid onset
Short half-life

Question 5

What is the onset time of Z-drugs?

Answer 5

within 30 minutes

Question 6

What is the half-life of z-drugs?

Answer 6

1-7 hours

Question 7

Where are Z-drugs agonists?

Answer 7

GABA A receptor

Question 8

What effect do Z-drugs have on GABA?

Answer 8

Increase GABA activity

Question 9

Describe the similarities between the pharmacology of z-drugs and that of BDZs.

Answer 9

Z-drugs bind to same site as BDZs
Both rely on presence of GABA to exert their effects.

Question 10

Describe the hypnotic and anxiolytic qualities of z-drugs.

Answer 10

Strong hypnotic
Poor anxiolytic

Question 11

Why have their been increased warnings associated with z-drugs over the last 15 years?

Answer 11

Increasing reports of complex and bizarre behaviours

Question 12

What are the 6 most commonly reported complex behaviours related to z-drugs?

Answer 12

Sleep eating
Sleepwalking with object manipulation
Sleep conversations
Sleep driving
Sleep sex
Sleep shopping

Question 13

What is the common theme amongst the complex behaviours associated with z-drugs?

Answer 13

Lack of memory upon waking