Yoho

Question 1

biomarkers for liver and bone disease

Answer 1

• Alkaline phosphatase –> liver and bone
  
  • number 1 marker for bone
• AST = HEART, LIVER, SKELETAL MUSCLE
• ALT = more specific for LIVER

Question 2

Clinical signs and diagnosis of DVT

Answer 2

• Bone scan
  
  • Tec99 –> measures bone regeneration
    
    • obstruction doesn’t light up as much
• Tests:
  
  • below knee go with Venogram
  • above knee use ultrasound
• Symtoms
  
  • erythema, bluish red tint to the leg

Question 3

Erythemia nodosum

Answer 3

• Hypersensitivity reactions
• red, tender, painful, pretibial nodules
• appears in crops
• systemic symptoms (fever, fatigue)
• more often a sign of other diseases (IBD, infections, TB, etc)

Question 4

Pyoderma gangrenosum clinical

Answer 4

• papulovesicle/pustule
• rapid necrosis
• necrotizing vasculitis
• erythematous halo with rolled borders
• painful, will heal wiht atrophic scar
• also related to RA, myeloproliferative diseases, hepatitis, drug rxns

Question 5

pathophysiology of pyoderma gangrenosum

Answer 5

• vasculitis appearing process
• inflammatory necrosis of blood vessel wall
• abnormal inmmunolgoc response
  
  • immuen complex depsotisiton
  • inflammatory infiltrates (NEUTROPHILIC)
  • fibrinoid necrosis of vessels
  • tissue infarction
  • ulceration

Question 6

Enteropathic arthritis

Answer 6

• ankylosing spondylitis (ass with back)
• PERIPHERAL ARTHIRTIS
  
  • classifed as seronegative spondyloarthropathy
  • 10-20% ass with IBD
  • may be first clinical sign of IBD
  • knees, ankles, and feet most commonly involved
  • LACK EROSIVE CHANGES (joint distension)
  • synovial fluid analysis (class II)
  • HLA-B27