Perry 1 Flashcards

1
Q

Define obesity

A
  • overweight = Body mass index (BMI) = 25-29.9
  • Obesity = BMI > 30
  • BMI = weight in relation to height (Kg/m^2)
  • BMI Categories
    • underweight = < 18.5
    • normal = 18.5-24.9
    • overweight = 25-29.9
    • obese = 30-39.9
    • Morbid obesity = 40-49
    • super obesity = 50 and above
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2
Q

Obesity impact

A
  • 300,000 deaths/year are obesity related
  • Increase mortality rates
    • 50% above ideal body weight (2x mortality rate
    • diabetic and 50% above ideal weight: 5x mortality rate
  • Increase Cancer risk
    • breast, endometrial, cerical, colon, prostate, kidney
  • Current generatino of american children will be the first in two centuries to have SHORTER LIFE EXPECTANCY THAN THEIR PARENTS
    • life shortening impact of obesity could ris 2-5 years
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3
Q

Morbid obesity

A
  • morbid obesity decrease life expectancy by 5-15 yrs
  • compared to normal wieght person, a 25 year old mrobidly obest man has 22% reduction in expected raminign lifespan
  • this is loss of 12 years
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4
Q

Dieting/medications for weight loss

A
  • Dieting and exercise
    • good for individual who need to lose < 30#
    • does not work for long term weight control for > 100#
  • Drugs
    • DMI > 30 or BMI > 27 with medical conditions
    • average weight loss 5-10% of body weight
    • ORLISTAT –> Blocks fat absorption
    • DIDREX, TENUATE, BELQIV, CONTRAVE –> decrease appetite
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5
Q

consequences of obesity

A
  • obesity is associated with a rise in comorbid conditions
    • type 2 diabetes
    • hyperlipidemia
    • HTN
    • obstructive sleep apnea
    • heart disease
    • asthma
    • back and lower extremity weight bearing degenerative problem
    • cancers
    • depression
    • ETC
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6
Q

Waist circumference

A
  • used to assess disease risk in adult with BMI < 35
    • >40 inches in men
    • > 35 inches in woemn
  • INCREASED RISK OF INSULIN RESISTANCE, DIABETES, elevated TG
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7
Q

HTN

A
  • most common disease assocaited with obesity
  • 10% weight gain –> increase BP by 6.5 mmHg systolic BP
  • Goal and tx
    • 10# weight loss
    • diet and exercise (DASH DIET)
    • surgery for severely obese
      • HTN is improved/resolved in 60-70% following bariatric sruery
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8
Q

DASH DIET

A
  • dietary approaches to stop hypertension
    • aims at prevent and control high blood pressur by limiting sodium to 2300 mg/day
    • Decrease systolic blood pressure by 7-12 points
  • High in potassium, phosphorus and protein
    • Not recommended for ESR disease
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9
Q

Dieabetes

A
  • obesity is the most powerful risk factor assocaited with type 2 diabetes
  • Goals:
    • lose weight
    • regulate BG
    • regulate blood lipids
  • TX
    • very low calorie diet
    • bariatric srugery (may improve type 2 diabetes
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10
Q

Heart disease

A
  • Obesity = indipendent risk factor for coronary artery disease
  • elevated cholesterol
  • BMI postively associated with INCREASE LDL and decrease HDL
    • the higher the BMI the higher the risk of heart disease
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11
Q

Metabolic syndrome

A
  • Insulin resistance syndrome; syndrome X
    • hyperinsulinemia
    • dyslipidemia
    • impaired glucose tolerance
    • HTN
  • Tx
    • increase omega-3 FA, increase fiber, lower glycemic index diet
    • exercise
    • surgery
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12
Q

cancers associated with Obesity

A

endometrial

postmenopausal breast

colon

kidney

pancreas, liver, gallbladder

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13
Q

External factors leading to obesity

A
  • energy balance
    • basal metabolic rate
    • thermic effect of food
    • physical activity
  • Environment
    • media
    • neighborhood
    • parents as role models for kids
  • Smoking
    • 1pack/day –> 10% increase calories burned
    • smoking cessation decrease metabolic rate
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14
Q

basal metabolic rate

A
  • involutnary activities
    • breathing
    • organ function
    • regulating body temp
      *
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15
Q

termic effect of food

A
  • amounnt of energy used to process/digest food
  • 8-10% of consumed energy for a mixed diet
    • proteins have higher thermic effect of food than fats and carbs
  • Negative caloric balance foods
    • celery
    • grapefruit
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16
Q

Internal factors leadign to obesity

A
  • Genetic factors
    • 40% of obesity attributed to hereditary factors
  • Food intake regulation
    • appetite (hunger, satiety)
    • hormones (signals) from gut (ghrelin, cholecystokinin)
    • Nutrient type/amount (protein)
    • timing of meals)
  • Fat cell metabolism
  • insulin
  • emotions/psychological factors
17
Q

Fat cell development/metabolism

A
  • Energy in exceeds energy out
    • stored in fat cells of adipose tissue
  • Body fat
    • number and size of fat cells
      • perioids in life when fat cell numbers increase
      • cell proliferation
  • Energy out eceeds energy in
    • fat cell size decreases; no change in number
  • Lipoprotein lipase (LPL) activity
    • storage of TG
    • obese vs lean people
18
Q

Body fat distribtuion

A
  • Men = apple shape (fat stored in upper parts of body
    • assocaited with heart disease, stroke, diabetes, HTN
  • Women = pear shape (fat stored in hips and thigh)
    • assocaited with chronic diseases (less detrimental)
19
Q

INSULIN

A
  • increase insulin equals increase fat storage
  • levelds depend on:
    • heredity
    • sensitivity to food cues
    • food consumed
    • phsyical activity