Yersinia

Question 1

Gram—-/—-

Answer 1

negative/ cocco bacillus

Question 2

aspiration

Answer 2

faculttaive anarobic rods

Question 3

fermenter?

Answer 3

fermenter

Question 4

—–is covered with a protein capsule

Answer 4

Y. pestis

Question 5

there are 3 different species of yersinia:

Answer 5

Yersinia pestis (plague)
Yersinia enterocolitica
 Yersinia pseudotuberculosis

Question 6

some species like—-can grow at really cold temperatires so they can grow to high numbers in contaminated, refrigerated food or blood
products)

Answer 6

Y. enterocolitica)

Question 7

most devastating disease in history

Answer 7

plague (yersinia pestis)

Question 8

epedmiology of yersinia:

Answer 8

Africa Madagascar, Tanzania, Democratic Republic of the Congo, Vietnam, Mozambique, Namibia.
Peru, Arizona, California, Colorado, and New Mexico

Question 9

transmission:

Answer 9

the plahue can be transmitted to humans in the folloiwngs ways:
1) flea bits: bubonic or septicimic
2)Contact with contaminated fluid or tissue of a plague infected animal. Cause bubonic
or septicemic plague
3) Infectious droplets: pneumonic plague

Question 10

Yops

Answer 10

Yersinia outer proteins are a group of virulence fcators produced by yerisnina pestis they:
1)desphophspherylate several proteins requied for phagocytosis
2)disurput actin filmanets
3)apoptosis

Question 11

virulence factors that yersinia has genes for:

Answer 11

1) Yops
2) type 3 secretion systems
3)siderophores
4)(F1) gene: coding for capsule: inhibition of phagocytic
migration and engulfment
5)plasminogen activator (Pla) protease gene:
 inhibition of platelet aggregation
 prevent opsonization (inhibit C3b) and phagocytic migration

Question 12

comparison between bubonic and pnenominc plagues

Answer 12

slide 12

Question 13

diseases caused by Y. pestis:

Answer 13

1) bubonic plague (most common)
2) septicimia plague
3)pulmunary plague SLIDE 13 FOR MORE DETAILS ON THEM ALL

Question 14

pulmonary plague: is —-and is usually complicated by —

Answer 14

fulminant/sepsis

Question 15

the patients of this plague are highly infectious and and person to person spread occurs by aersols.

Answer 15

pulmonary plague

Question 16

Which plague bacteria show bipolar staining and what is it

Answer 16

Septicmic plage slide 15

Question 17

Appropriate diagnostic specimens of Y pestia include

Answer 17

Blood cultures/ bubo aspirates/ sputum, tracheobronchial washes, swabs of skin lesions or pharyngeal mucosa, and cerebrospinal fluid

Question 18

While Y pestis is obtained through the 3 aforementioned methods, Y entercolitica and Y pseudotubeculosis are transmitted through ——

Answer 18

Aquired by ingestion
and multiplication mesenteric ganglia which leads to enterocolitis (inflammation of both SI and colon) fever and diarrhea

Question 19

They can also cause

Answer 19

Can cause septicemia, arthritis, abscess (in fragile people)

Question 20

Diagram of transmission

Answer 20

Slide

Question 21

Shape of Y entercolitica and pseudotubeculosis

Answer 21

Pleomorphic bacilli

Question 22

Y entercolitica spread contaminated ——

Answer 22

Food/ water or blood products

Question 23

Other manifestations in adults are——

Answer 23

Arthirits- septicemia- intrabadominak abscess- hepatitis, and osteomyelitis

Question 23

Symptom s

Answer 23

Gastroenteritis: diarrhea, fever, and abdominal pain that last for as long as 1 to 2
weeks. (months if chronic) (appendicitis like symptoms)

Question 24

2/3 of all entercolitica infections are

Answer 24

Entercolitis

Question 25

Y tuberculosis can also produce

Answer 25

enteric disease with the same clinical features.