Wound healing - Tissue mediators Flashcards

1
Q

PDGF

A
  • Secreted by activated platelets and macrophages
  • Induces vascular remodeling and smooth muscle cell migration
  • Stimulates fibroblast growth for collagen synthesis
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2
Q

FGF

A

Stimulates angiogenesis

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3
Q

EGF

A

Stimulates cell growth via tyrosine kinases (EGFR/ErbB1)

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4
Q

TGF-β

A

Angiogenesis, fibrosis, cell cycle arrest

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5
Q

Metalloproteinases

A

Tissue remodeling

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6
Q

VEGF

A

Stimulates angiogenesis

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