Tumor suppressor genes Flashcards by Paul Kim | Brainscape

Q

APC

A

Colorectal cancer (associated with FAP)

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Q

BRCA1/BRCA2

A

Breast and ovarian cancer

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Q

CDKN2A

A

Melanoma

pancreatic cancer

p16, blocks G1–>S phase

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Q

DCC

A

Colon cancer

DCC—Deleted in Colon Cancer

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Q

DPC4/SMAD4

A

Pancreatic cancer

DPC—Deleted in Pancreatic Cancer

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Q

MEN1

A

MEN 1

Menin

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Q

NF1

A

NeuroFibromatosis type 1

Ras GTPase activating protein (neurofibromin)

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Q

NF2

A

NeuroFibromatosis type 2

Merlin (schwannomin) protein

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Q

PTEN

A

Breast cancer

prostate cancer

endometrial cancer

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Q

Rb

A

Retinoblastoma

osteosarcoma

Inhibits E2F
blocks G1–>S phase

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Q

TP53

A

Most human cancers

Li-Fraumeni syndrome

p53, activates p21, blocks G1–>S phase

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Q

TSC1

A

Tuberous sclerosis

Hamartin protein

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Q

TSC2

A

Tuberous sclerosis

Tuberin protein

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Q

VHL

A

von Hippel-Lindau disease

renal cell carcinoma

Inhibits hypoxia inducible factor 1a

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Q

WT1/WT2

A

Wilms Tumor (nephroblastoma)

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