Wound healing Flashcards
Difference between regeneration and repair?
- Regeneration: Replace damage tissue with the tissue itself
- Repair: Replaces damaged tissue with fibrous scar
Mention the 3 types of tissue based on the regenerative capacity?
Labile tissue
Stable Tissue
Permanent tissue
What type of tissue are these?
- Myocardium
- Liver
- Small and large bowel
- Bone marrow
- Skeletal muscle
- Neurons
- Skin
- Proxima tubule of the kidney
- Myocardium: Permanent
- Liver: Stable
- Small and large bowel: Labile
- Bone marrow: labile
- Skeletal muscle: permanent
- Neurons: permanent
- Skin: labile
- Proxima tubule of the kidney: stable
What tissues undergo repair?
Myocardium
Neurons
Skeletal muscle
Each type of collagen is found in what tissues?
Type 1: Bone
Type II: Cartilage
Type iii: Blood vessels, granulation tissue, embryonic tissue
Type iv: Basement membrane
What are the major components of granulation tissue?
fibroblasts
Capillaries
Myofibroblast
what are the steps for a scar formation
Type iii collagen is replaces with type i collagen by collagenase (requires zinc as cofactor)
Function of
- TGF alfa
- TGF B
- PDGF
- FGF
- VEGF
- TGF alfa: epithelial and fibroblast factor
- TGF B: Fibroblast GFm inhibit inflammation
- PDGF: Endothelium, smooth muscle, fibroblast GF
- FGF: angiogenesis**, skeletal development
- VEGF: angiogenesis
Patient with a large wound that is healed by 2nd intention. 6wk later you notice that the size of the wound has reduced its size. What is the mechanism by which this wound actually reduce in size?
Myofibroblast of granulation tissue
Name the causes of delayed wound healing
Infection Vitamin C deficiency Copper deficiency Zinc deficiency Ohers( foreign body, ischemia, diabetes, malnutrition)
Dehiscence is most commonly seen in what type of surgery?
abdominal surgery
What type of collagen excess are hypertrophic and keloid scar made up?
hypertrophic scar: Type I
keloid scar: Type III
