Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pathoma > Acute inflammation I > Flashcards

Acute inflammation I Flashcards

1
Q

Hallmark of acute inflammation

A

Neutrophils

Edema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Hallmark of chronic inflammation

A

Lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What can cause acute inflammation

A

Inflammation

Tissue necrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

difference between Innate and adaptive immunity

A

Innate: Non Specific, Immediate response, Cells ( mast cells, MO, Neutrophils, Eos, baso)
Adaptive: Specific response, Longer response, Lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are the components of the innate immunity

A

Epithelium
Mucous secreted by cells
Complement system
Cells ( mast cells, MO, Neutrophils, Eos, baso)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the factors of immune system?

A
  • TLRs
  • Arachinodic Acid
  • Mast Cells
  • Complement
  • Hageman Factor
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The TLRs recognize what?

A

PAMP (Pathogen associated molecular patterns)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

The LPS of GN bacteria is recognized by?

A

CD14 from Macrophagues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How does the TLR’s activates the immune response?

A
  1. TLR recognizes PAMP
  2. TLR activates
  3. Upregulation of NF- KB
  4. NF- KB activated
  5. Activates immune response genes
  6. Leads to the production of multiple immune mediators
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

T/F TLRs are only found in the innate immunity

A

False

They are also found in the adaptive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Origin of Arachinodic Acid

A

Is released form the phospholipid cell membrane by phospholipase A2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the 2 pathways in which te arachinodic acid acts

A
  1. Cyclooxygenase Pathway

2. 5- lipooxygenasa Pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are key PG in the Cyclooxygenase Pathway?

A

PGI2, PGD2, PGE2

***Vasodilation and increase of vascular permeability
PGE2: Fever and pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are key Leukotrines in the Cyclooxygenase Pathway?

A

LTB4– Attracts and activates neutrophils

LTC4, LTD4, LTE4– Vasoconstriction, bronchoespasm and increase vascular permeability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the 4 key mediators that attracts and activate neutrophils

A

LTB4
C5a
IL 8
Bacterial Products

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Where are find the mast cells?

A

Connective tissue

17
Q

How are activated mast cells?

A

Tissue trauma
Complement proteins C3a and C5a
Cross linking of cell surface IgE by antigen

18
Q

How is the immediate response of Mast Cells

A

Release of preformed histamine granules

mediates vasodilation of arterioles and increase vascular permeability

19
Q

How is the delayed response of Mast Cells

A

Production of arachidonic acid, metabolites, particularly leukotriens

20
Q

Pte has mast cells that activates the acute inflammatory response and several hours later the acute inflammatory response continue. What is the major mechanism by which mast cells will allow for the progression of the acute inflammatory response?

A

Production of arachidonic acid and leukotriens

21
Q

What is a complement?

A

Group of proinflammatory serum proteins that complements inflammation

22
Q

How is the complement activation?

A

Classical Pathway
Alternative Pathway
Mannose binding lectin PAthway

23
Q

How does the classical pathway activates the complement?

A

C1 binds to IgG or IgM that is bound to antigen

“GM makes classical cars”

24
Q

What are the results of activation of complement?

A

C3 convertase
C5 convertase
MAC (Membrane attack complex)

25
Q

What is mechanism of MAC?

A

Lyses microbes by creating holes in cell mebrane

26
Q

Function of C3a and C5a?

A

Trigger most cell degranulation

27
Q

Function of C5a

A

Chemotactic for neutrophils

28
Q

Function of C3b?

A

opsonin for phagocytosis

29
Q

Hageman factor is related with what pathology?

A

DIC

This activates the coagulation and fibrinolytic

30
Q

What are the 2 molecules that mediates pain?

A

PGE2

Bradykinin

31
Q

What are the cardinal signs of inflammation

A 
Redness
Warmth 
Swelling
Pain 
Fever
32
Q

Key mediator of rubor and calor

A

HISTAMINE
PG
Bradykinins

33
Q

Key mediator of swelling

A

Histamine

Tissue damage

34
Q

Key mediator of Pain

A

Bradykinin and PGE2 sensitize sensory nerve endings

35
Q

Mechanism of fever

A

Pyrogens cause macrophages to release IL 1 and TNF
Activates perivascular ell of hypothalamus and increase COX activity
Increase PGE2

Pathoma (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions