Neoplasia

Question 1

Name the principles of neoplasia?

Answer 1

Unregulated, irreversible and monoclonal

Question 2

The clonality can be determined by what type of isoforms?

Answer 2

G6PD isoforms (ratio 1:1)
androgen receptor isoforms

Question 3

The clonality of B cells is determined by?

Answer 3

Ig light chain phenotype

Question 4

Patient with enlarged lymph node. DDX

Answer 4

Metastatic cancer
Reactive hyperplasia
Lymphoma

Question 5

Patient with an enlarged lymph node. A biopsy is performed that shows the proliferation of lymphocytes. the light chain is studied. the ratio is 20:1. DX?

Answer 5

Lymphoma

Question 6

Origin of tissue of

• Carcinoma
• Sarcoma
• Lymphoma
• Melanoma

Answer 6

• Carcinoma: Epithelium
• Sarcoma: Mesenchyme
• Lymphoma: Lymphocyte
• Melanoma: Melanocyte

Question 7

Name the 3 causes of death in adults

Answer 7

1. CV disease
2. Cancer
3. Cerebrovascular disease

Question 8

Name the 3 causes of death in children

Answer 8

1. Accidents
2. Cancer
3. congenital defects

Question 9

Most common cancer in adults by incidence and mortality

Answer 9

Incidence: 1) breast/prostate 2)lung 3) colorectal

Mortality 1.lung 2.breast/prostate 3. colorectal

Question 10

How many divisions have to occur before symptoms arise?

Answer 10

30 divisions

Question 11

What are the goals of screening

Answer 11

1. Catch displasia before it becomes carcinoma

2. Detect carcinoma before clinical symptomas arise