Wound Healing Flashcards
Which of the following regarding the inflammatory (reactive) phase is TRUE?
(1) It occurs immediately after injury.
(2) It includes hemostasis, but not removal of necrotic tissue
(3) There is decreased vascular permeability
(4) TGF beta causes activation of proteases and prevents scar tissue formation.
(1) Hemostasis occurs immediately after injury.
TGF-beta is activated during the inflammatory (Reactive phase). Its function is to:
cause inhibition of proteases; scar tissue formation occurs.
The reparative process with re-epithelialization, matrix synthesis and neovascularization to relieve the ischemia of the trauma itself.
(1) Inflammatory (reactive) phase
(2) proliferative phase
(3) Maturational phase
(1) proliferative phase
The proliferative phase occurs as
(1) acute responses of hemostasis and inflammation continue
(2) There is scaffolding and angiogenesis
(3) Two weeks post-wounding and angiogenesis 3 - 7 days.
The proliferative phase occurs as (2) there is scaffolding and angiogenesis.
The lag phase of the proliferative phase is characterized by:
(1) the absence of fibroblasts
(2) is over 7 days in length.
(3) The time for undifferentiated mesenchymal cells to differentiate into specialized fibroblasts.
(3) The time for undifferentiated mesenchymal cells to differentiate into specialized fibroblasts.
Wound contraction occurs during the
(1) Inflammatory (Reactive) phase
(2) proliferative phase
(3) maturational phase
(3) maturational phase
The maturational phase involves wound contraction. This results from:
myelofibroblasts
T/F: tensile strength of a scar is 30% less than that of normal tissue.
True.
Wound strength increases rapidly within ____ and plateaus up to 1 year.
Wound strength increases rapidly within 1 - 6 weeks and plateaus up to 1 year.
Around the third day of a post-wound, the major cell type present is:
(1) neutrophils
(2) macrophages
(3) fibroblasts
(2) macrophages
Fibroblasts peak post-wounding
(1) day 2
(2) day 3
(3) day 5
Fibroblasts peak post-wounding (3) day 5.
The provisional matrix is composed of:
(1) fibrin
(2) fibrinogen
(3) fibronectin
(4) All of these
(4) ALl of these.
The end result of the provisional matrix is:
collagen
The predominant component of the inflammatory phase is
fibronectin
As the inflammatory phase breaks down, the majority of collagen that is the FINAL result is:
collagen type 1
Matrix metalloproteinases are downregulated by:
TGF-beta
The activation of plasminogen results in
matrix degradation and facilitates cell migration.
The most common type of collagen (the type of collagen found in skin and bone) is:
type 1 collagen
Early wound healing is characterized by increased expression of:
(1) type 1 collagen
(2) type 2 collagen
(3) type 3 collagen
(3) type 3 collagen
Scurvy is a result of vitamin C deficiency. When vitamin D is deficient, there is prevention of:
There is prevention of proline hydroxylation and the formationf unstable triple helices.