Liver, Pancreas and Spleen Flashcards
The pancreas is a retroperitoneal organ that extends oblique from the duodenal loop to the hilum of the ___.
spleen.
T/F: the vasculature that supplies the pancreas and spleen drains into the portal vein and goes to the liver.
True.
Alpha pancreatic cells are associated with:
Glucagon production, as well as CCK, endorphin.
A patient with a glucagonoma is MOST likely to present with:
(1) necrolytic migratory erythema
(2) pre-diabetes
(3) HHyperaminoacidemia
(1) necrolytic migratory erythema.
Beta pancreatic cells are associated with:
insulin production, as well as amylin, CGRP and prolactin.
A patient with an insulinoma is MOST likely to present with:
(1) hyperglycemia
(2) hypoglycemia and associated symptoms.
(2) hypoglycemia and associated symptoms.
D pancreatic cells produce
Somatostatin
A somatostainoma presents with
diabetes, gallstones and steatorrhea.
D2 pancreatic cells produce
VIP
A VIPoma presents with
High volume secretory diarrhea, hypokalemia, metabolic acidosis and hypochlorhydria.
T/F: Pancreatic G cells are not present in normal physiologic states.
True.
The chief physiologic function of the endocrine pancreas is:
regulation of body energy.
Insulin causes the physiologic functions:
(1) increasing protein synthesis.
(2) increasing glycogenolysis
(3) increasing lipolysis
(1) increasing protein synthesis.
Glucagon release energy by increasing blood glucose level via stimulation of:
glycogenolysis, gluconeogenesis and lipolysis.
A patient presents with a skin rash and diabetes. The patient has noticed weight loss and fatigue. Labs show anemia. The patient MOST likely has:
A glucagonoma.
A patient with a glucagonoma presents with characteristic skin rash (necrolytic migratory erythema). Reduction of the erythema involves treatment via:
parenteral administration of amino acids.
Glucagonoma is treated via:
surgical excision of the tumor.
A patient presents with fatigue and mental confusion. Labs show hypoglycemia and catecholamine surge. You diagnose the patient with an insulinoma. Treatment of the condition should involve:
IV administration of glucose.
The type of pancreatic tumor that is associated with MEN 1 syndrome
Insulinoma
Treatment of insulinoma involves:
IV administration of glucose and surgery (enucleation).
Which of the following regarding gastrinomas is TRUE?
(1) Most originate in the duodenum.
(2) It is the most common islet cell tumor but is rarely symptomatic.
(3) 45 - 60% of gastrinomas arise in the “gastrinoma triangle”.
(3) The duodenum is the site of gastrinomas in 45 - 60% of patients.
A patient presents with abdominal pain and diarrhea. Endoscopy shows peptic ulcers and increased gastric acid production. You diagnose the patient with Zollinger-Ellison syndrome. The diarrhea will subside upon treatment via:
Nasogastric aspiration of gastric secretion.
MOST patients with Zollinger-Ellison syndrome have:
MULTIPLE duodenal peptic ulcers.
Diagnosis of Zollinger-Ellison syndrome depends on
The presence of gastrinemia in the face of increased secretion of gastric acid (AKA there is no feedback for gastrin secretion).
Clinical clues for patients with ZES include:
(1) a virulent peptic ulcer or GERD diathesis.
(2) Absence of h. pylori or a failure of the peptic ulcer to heal after H2 blocker use.
(3) Secretory diarrhea that resolves.
(4) Absence of MEN-1 syndromes.
(1) A virulent peptic ulcer or GERD diathesis.
(2) Absence of h. pylori or a failure of the peptic ulcer to heal after H2 blocker use.
T/F: Pharmacologic control of acid secretion has rendered total gastrectomy unnecessary. Operation is used only for tumor removal.
True.
T/F: though gastrinomas have a high rate of malignancy, they are more apt to be cured than is cancer of any other abdominal viscus.
True.
ZES may present with:
pituitary tumors and abnormal PTH secretion.
A patient presents with diabetes, steatorrhea and gallstones. Labs show hypochlorhydria. You diagnose the patient with a somatostatinoma. Treatment considerations include:
70 - 80% of the tumors are malignant and surgical treatment, as well as CHOLECYSTECTOMY should be performed.
Somatostatinoma tumors are most common at:
the tail of the pancreas.
A patient presents with profound watery diarrhea, hypokalemia and achlorhydria. The secretory diarrhea persists despite fasting and nasogastric aspiration. Stool volume is more than 700 mUday. The patient’s diagnosis is MOST likely:
VIPoma.
A patient presents with profound watery diarrhea, hypokalemia and achlorhydria. The secretory diarrhea persists despite fasting and nasogastric aspiration. You diagnose the patient with a VIPoma. Treatment involves:
Surgical removal of VIPoma in ALL patients, as well as treatment with octreotide to control fluid loss.
T/F: acute pancreatitis occurs when there is an insult to the pancreas. When the insult stops, the pancreas goes back to normal.
True.
Which of the following regarding pancreatitis is TRUE?
(1) It is more common in males than females.
(2) Acute interstitial pancreatitis presents with severe inflammation.
(3) Pancreatic fluid collections are usually infected.
(1) Pancreatitis is more common in males than females.
The MOST common cause of acute pancreatitis worldwide is:
gallstone pancreatitis
The risk of gallstone pancreatitis increases with:
smaller stones.
Which of the following regarding alcoholic pancreatitis is TRUE?
(1) It is the most common cause of pancreatitis worldwide.
(2) It is more prevalent in young women than in young men.
(3) THere is no genetic predisposition and smoking is not reatled to its development.
(4) Compared with nonsmokers, the relative risk of alcohol induced pancreatitis in smokers is 4.9.
(4) Compared with nonsmokers, the relative risk of alcohol-induced pancreatitis in smokers is 4.9.
Abnormal flow of pancreatic juice into the duodenum can result in:
pancreatic injury.
Patients with pancreatic cancer usually do not develop:
pancreatitis.
T/F: Drugs make up a significant portion of pancreatitis cases.
False.
Which of the following is a cause of pancreatitis?
(1) hypertriglyceridemia
(2) hereditary
(3) autoimmune
(4) scorpion sting/gila monster bite
(5) hypercalcemia (hyperPTH)
(6) All of these
(6) All of these.
The pathogenesis of pancreatitis begins with:
generation of increased active trypsin that has no negative feedback.
The pathogenesis of pancreatitis involves the continued synthesis of pancreatic enzymes. Inflammation, thrombosis and hemorrhage is a result of:
enzyme damage to the vascular endothelium, leading to vasoconstriction, capillary stasis and decreased oxygen saturation.
The diagnosis of acute pancreatitis requires two of the following three features:
(1) abdominal pain with acute onset, severe epigastric pain that radiates to the back.
(2) threefold or higher elevation of serum amylase or lipase levels above normal.
(3) Characteristic findings of pancreatitis by imaging.
Clinical characteristics of acute pancreatitis include:
(1) hypoglycemia
(2) leukopenia
(3) elevation of liver enzyme levels (ALT).
(3) Elevation of liver enzyme levels (ALT).
T/F: simple abdominal radiographs are useful for diagnosis of pancreatitis.
False.
In regards to imaging for acute pancreatitis:
US should be ordered in ALL patients and CT is the best modality for elevation of the pancreas.
The most valuable CT contrast phase in which to evaluate the pancreatic parenchyma is the:
portal venous phase (65 - 70 seconds after injection of contrast material).