Wound Closure Biomaterials Flashcards
Bladder, fascia, and skin - which one heals the fastest?
The bladder heals very fast, and the fascia and skin take a lot longer. Can use quick absorbing material for sutures in the bladder.
Which 2 tissues are the only tissues that reach 100% tissue strength after healing?
Bladder and bone
Ideal Suture Material
- High initial tensile strength but totally biodegradable at a predictable rate
- Bioinert
- Good handling characterisitcs, strong, supple, lack of memory
- Absolute knot security without loss of strength at knot
- Inexpensive and easily sterilized
Tensile Strength vs Absorption
- Tensile strength: Refers to the strength of the suture and it’s ability to hold wound edges in apposition. As absorption occurs, tensile strength will diminish over time.
- Absorption: refers to the time needed for the body to absorb or dissolve the suture material
Nonabsorbale suture vs Absorbale suture
- Nonabsorbale suture: retaines tensile strength for longer than 60 days
- Absorbale suture: undergoes degredation and rapid loss of tensil strength within 60 days
What are the three suture structures?
- Monofilament
- Woven-braided
- Twisted (catgut)
List two natural absorbale sutures:
- Catgut
- Collagen
Catgut
- Derived from sheep small intestinal submucosa or cattle serosa
- Twisted multifilament
- Capillary action - can swell and become untied
- Absorption by phagocytosis
- Rate of absorption unpredictable from one package to the next
Two sutures that are degraded by phagocytosis
- Silk
- Catgut
Catgut can come in plain and chromic - when would you use one or the other?
- Chromic lasts longer
Synthetic Absorbales
Multifilament - braided
- Polyglactin 910 - Vicryl
- Polyglycolic acid - Dexon II
- Glycolide/lactide copolymer - Polysorb
Synthetic Absorbables
Monofilament
- Polydioxanone - PDS II
- Polyglyconate - Maxon
- Poliglecaprone 25 - Monocryl
- Glycomer 631 - Biosyn
- Polyglytone 6211 - Caprosyn
Polyglactin 910 - Vicryl
- Braided multifilament
- Absorbed by hydrolysis - compete absorption ~ 70 days
- Maintains adquate tensile strength for 14 to 21 days
- High coefficient of friction increases tissue drag - coating attmepts to minimize drag
- Not the best suture if you need a long lasting one!!
Polyglactin 910 - Vicryl Rapide
- Same as vicryl, but maintians adequate tensile strength for wound support for less than 14 days
- Used when fast absorption is advantageous
Polyglycolic acid - Dexon II
- Braided multifilament
- Absorbed by hydrolysis - enhanced in alkaline environment
- Maintains adequate tensile strength for 14-21 days
- Complete absorption 90-120 days
- High coefficient of friction increases tissue drag
- Similar to Vicryl, but handles less desirably than vicryl
Glycolide/lactide - Polysorb
- Braided multifilament
- Absorbed by hydrolysis - complete absorption ~ 70 days (similar to polyglactin 910 - Vicryl)
- Maintains ~ 80% tensile strength at 14 days
- Similar to vicryl
Polydioxanone - PDS II
- Monofilament
- Absorbed by hydrolysis - complete absorption by about 6 months
- Maintains 69% tensile strenght at 42 day
- Takes the longest to be absorbed (180-240)
- Tends to kink when used for continuous patterns
- Used for long-term support (fascia healing)
Polyglyconate - Maxon
- Monofilament
- Absorbed by hydrolysis - complete absorption ~ 180 days
- Maintains 55% of tensile strength at 21 days
- at 21 days is when fascia stops its rapid regaining of strength
- Handling characteristics similar to PDS