WK13: ASO Test Flashcards
globulin, occurring mostly in the gamma globulin fraction of the serum
ASO antibody
Antistreptolysin O can be specifically fixed with the antigen ________, inhibiting its hemolytic activity
streptolysin O
Streptolysin O is _____, eliciting the formation of antibodies that effectively neutralizes its hemolytic action.
antigenic
A high proportion of patients with streptococcal infections show an antibody response during _______
convalescence
most widely used test for SLO is the ___________ used to detect ASO in serum.
neutralization (ASO titration) test
True or False:
In the interpretation of ASO titers, many variables, including age, the severity of the infection, previous exposure to streptococcal infection, and the individual’s ability to respond immunologically to the toxin, does not need to be taken into account, since no set ‘normal’ titer has been established.
False (must be taken into account)
Most healthy adults have ASO titers of
125 Todd units (or less)
amount of antibody that completely
neutralizes two and one-half minimal hemolytic doses of SLO
One Todd Unit
Children ASO titers range from
5-125 Todd Units
True or false:
A rise in ASO titer of at least 30 percent over the previous level is usually regarded as significant
True
In cases of rheumatic fever and glomerulonephritis, a
marked increase in ASO titer is often seen during the _________ preceding an attack of the illness.
symptom-free period
True or False:
antibiotics, hormones and drugs for rheumatic fever inhibit the production of toxin
False (antibiotics, hormones, and cortisone)
True or false:
Very high titers are observed in all states of the nephritic syndromes
low titers
erythrocytes are coated with a crude mixture of streptococcal antigens is available
particle agglutination test
True or False:
Antistreptolysin O titration allows the qualitative analysis of the antibody, based on an internationally recognized unit system
quantitative
