Wk 4 important stuff

Question 1

Which Ig is responsible for blood grouping?

Answer 1

IgM

Question 2

Which Ig is not useful as a standalone test?

Answer 2

IgE

Question 3

Which Ig is the first to respond?

Answer 3

IgM

Question 4

1) Which Ig is tiny?
2) Which is largest?

Answer 4

1) IgG
2) IgM

Question 5

Which Ig will stay around for a long time?

Answer 5

IgG

Question 6

Which Ig is pretty unknown?

Answer 6

IgD

Question 7

Which Ig is most common?

Answer 7

IgG

Question 8

Which Igs cross the placenta?

Answer 8

IgG does, IgM does not

Question 9

Elevated IgM in newborn indicates what? Why?

Answer 9

In utero infection; IgM doesn’t cross placenta

Question 10

1) What is hypersensitivity? What is the severity?
2) How is it classified?

Answer 10

1) Exaggerated immune response with varying severity; uncomfortable to fatal
2) Into 4 types in the Gell and Coombs system (types I-IV) (questionable clinical significance but widely used)

Question 11

What type of hypersensitivity rxn is NOT antibody mediated?

Answer 11

Type IV

Question 12

1) What is an antibody rxn also called?
2) What is an immune complex rxn also called?
3) What is a delayed rxn also called?

Answer 12

1) Type II hypersensitivity
2) Type III
3) Type IV

Question 13

What might be seen on the CBC of someone with HIV?

Answer 13

Leukopenia, lymphopenia, and sometimes thrombocytopenia

Question 14

Which part of a transfusion rxn results in the most damage?

Answer 14

Recipient’s plasma antibodies vs donor’s erythrocyte antigens

Question 15

Which test is very specific for HIV?

Answer 15

ELISA