WHO 2016

Question 1

True of primary CNS lymphomas except:
A. Account for 2.4-3% of all brain tumors
B. Can affect any age
C. With peak incidence during the 5th-7th decade of life
D. Male-female ratio of 2:3
E. In immunocompetent individuals, viruses do not play a role

Answer 1

D. Male-female ratio of 2:3 (MF ratio of 2:2, p. 272)

Question 2

True of imaging findings of primary CNS lymphomas except:
A. Hypointense on T1, isointense to hyperintense on T2
B. Densely enhancing
C. Peritumoral edema is more severe than in malignant gliomas and metastases
D. With steroid therapy, lesions may vanish within hours

Answer 2

C. Peritumoral edema is more severe than in malignant gliomas and metastases (less severe, p. 272)

Question 3

True of immunophenotype characteristics of primary CNS lymphomas except:
A. CD 19 and 20 positive
B. CD 10 expression is frequent
C. Ki-67 index exceeds 70%
D. EBV should prompt evaluation for underlying immunodediciency

Answer 3

B. CD 10 expression is frequent (p. 273)

Question 4

True of prognosis & predictive factors of primary CNS lymphomas except:
A. PCNSL has a worse outcome than does systemic diffuse large B cell lymphoma
B. Age > 65 years is a major negative prognostic factor
C. Inclusion of WBRT with high dose MTX chemo may improve outcome
D. In elderly patients with methylated MGMT, temozolamide is therapeutically ineffective

Answer 4

D. In elderly patients with methylated MGMT, temozolamide is therapeutically ineffective (p. 275)

Question 5

The following features of AIDS-related diffuse large B cell lymphoma distinguishes it from primary CNS lymphoma in immunocompetent patients, except:
A. More frequent multifocal presentation
B. Associated with EBV
C. Tendency to contain more and larger areas of necrosis
D. Highly cellular, diffusely growing

Answer 5

D. Highly cellular, diffusely growing (p. 276)

Question 6

Most common dural lymphoma:
A. Diffuse large B cell lymphoma
B. Low grade B cell lymphoma
C. T-cell lymphoma
D. MALT lymphoma

Answer 6

D. MALT lymphoma (p. 277)

Question 7

This tumor is characterized by a biphasic pattern with variable proportions of compacted bipolar cells with Rosenthal fibers and loose, textured multipolar cells with microcycsts and occasional granular bodies*
A. Pilocytic astrocytoma
B. Pleomorphic xanthoastrocytoma
C. Glioblastoma
D. Ependymoma
E. Medulloblastoma

Answer 7

A. Pilocytic astrocytoma (p. 80)

Question 8

A variant of meningioma that consists of spindled cells forming parallel, storiform, and interlacing bundles in a collagen-rich matrix*
A. Meningothelial
B. Fibrous
C. Papillary
D. Transitional
E. Angiomatous

Answer 8

B. Fibrous (p.237)

Question 9

Which of the following has the best long term survival considereing proper treatment?*
A. Glioblastoma
B. Germinoma
C. Pineoblastoma
D. Medulloblastoma

Answer 9

B. Germinoma (based on WHO grade)