Katzung 13th

Question 1

CYP450 system involved in the metabolism of clopidogrel*
A. CYP 2C20
B. CYP 2C19
C. CYP 2C18
D. CYP 2C17
E. CYP 2C16

Answer 1

B. CYP 2C19

Question 2

Acts on GABA B receptors*
A. Tiagabine
B. Vigabatrin
C. Baclofen
D. Pregabalin
E. Gabapentin

Answer 2

C. Baclofen

Question 3

What is the first neurotransmitter discovered in the 1950s?*
A. Acetylcholine
B. Glutamine
C. Serotonin
D. Histamine

Answer 3

A. Acetylcholine

Question 4

Which of the following are among the mechanisms of action of CNS drugs at the synaptic and post-synaptic sites?*
A. They may act as receptor agonists.
B. They may decrease the breakdown of neurotransmitters.
C. They affect the storage and synthesis of neurotransmitters.
D. All of the above

Answer 4

D. All of the above (Fig 21-4)

Question 5

Which is true about pregabalin and gabapentin?*
A. Actus on alpha-2-delta subunit of Na channels
B. Excreted in the urine almost unchanged
C. Acts on voltage gated Ca channels
D. All of the above

Answer 5

C. Acts on voltage gated Ca channels

Question 6

Which of the following is NOT true about receptors?*
A. The mechanism of action of a drug is due to receptor-mediated actions.
B. Some drugs regulate the function of receptors as agonists or antagonists.
C. A change in the chemical structure of a drug will not change its affinity for a receptor.
D. A change in the chemical structure of a drug can result in alterations in therapeutic and toxic effects.

Answer 6

C. A change in the chemical structure of a drug will not change its affinity for a receptor.

Question 7

Which of the following does NOT act on a sodium channel?*
A. Valproate
B. Phenytoin
C. Ethosuximide
D. Carbamazepine

Answer 7

C. Ethosuximide

Question 8

True of carbidopa*
A. Intake of food does not affect absorption of the drug
B. Reduces the daily requirements of levodopa by approximately 75%
C. When given in combination with levodopa, adverse GI effects are more frequent
D. None of the above

Answer 8

B. Reduces the daily requirements of levodopa by approximately 75%

Question 9

Severe hepatotoxicity among AchE inhibitors*
A. Tacrine
B. Donepezil
C. Rivastigmine
D. Galantamine

Answer 9

A. Tacrine

Question 10

GABA-A agonist used for sedation*
A. Flumazenil
B. Lorazepam
C. Pentobarbital
D. Zolpidem

Answer 10

B. Lorazepam

Question 11

NMDA-R antagonist used in the treatment of alcohol dependence*
A. Naltrexone
B. Acamprosate
C. Disulfiram
D. Fomepizole

Answer 11

B. Acamprosate

Question 12

Mechanism of action of phenytoin at therapeutic levels*
A. Increases calcium permeability across the cell membrane
B. Increases the synaptic release of glutamate
C. Reduction of the release of GABA
D. Blocks Na channels and inhibits generation of rapidly repetitive action potentials

Answer 12

D. Blocks Na channels and inhibits generation of rapidly repetitive action potentials

Question 13

Which of the following is/are NOT dose dependent adverse effects of AEDs?*
A. Phenytoin: gingival hyperplasia, hirsutism
B. Valproic acid: weight loss, alopecia
C. Carbamazepine: diplopia, ataxia
D. All of the above are dose dependent adverse effects

Answer 13

D. All of the above are dose dependent adverse effects

Question 14

True of dexmedetomidine*
A. Highly selective a2-adrenergic antagonist
B. Clearance is high
C. Elimination half-life is long
D. Tolerance and dependence does not develop from it

Answer 14

B. Clearance is high

Question 15

Sensitizes brainstem vasomotor centers to inhibition by baroreflexes*
A. Methyldopa
B. Clonidine
C. Metoprolol
D. Captopril

Answer 15

B. Clonidine