Neuropath (Other textbooks)

Question 1

What are the three neurons that are especially vulnerable to hypoxic damage?

Answer 1

1. Pyramidal neurons in the CA1 field of hippocampus
2. Pyramidal neurons in layers 3 and 5 of the neocortex
3. Purkinje cells in the cerebellum
   (Ellison’s p. 6)

Question 2

A process wherein dead neurons become encrusted and replaced by mineral salts, particularly prominent in the infant brain in response to hypoxic-ischemic damage
A. Ferrugination
B. Nuclear drop out
C. Ballooning
D. Microvacuolation

Answer 2

A. Ferrugination (Ellison’s, p. 6)

Question 3

Small spherical nuclear inclusions that are brightly eosinophilic and are often seen in neurons of the adult substancia nigra most common in the elderly and in dementia with Lewy bodies
A. Marinesco bodies
B. Hirano bodies
C. Lafora bodies
D. Bunina bodies

Answer 3

A. Marinesco bodies (Ellison’s p. 7)

Question 4

Brightly eosinophilic rod-shaped or elliptical cytopasmic incluaions that may appear to overlap the edge of a neuron, most numerous in the CA1 field of the hippocampus
A. Marinesco bodies
B. Hirano bodies
C. Lafora bodies
D. Bunina bodies

Answer 4

B. Hirano bodies (Ellison’s p. 8)

Question 5

Inclusions with a round core that is intensely PAS-positive and are composed of polyglucosans, linked with aberrant glycogen hyperphosphorylation
A. Marinesco bodies
B. Hirano bodies
C. Lafora bodies
D. Bunina bodies

Answer 5

C. Lafora bodies (Ellison’s p. 8)

Question 6

Stain used to demonstrate enzyme deficiency in McArdle disease
A. NADH
B. Acid phosphatase
C. Myophosphorylase
D. Phosphofructokinase

Answer 6

C. Myophosphorylase (Escourolle, p. 280)

Question 7

ATPase activity is weak at alkaline pH but strong at acidic pH
A. Type 1 fibers
B. Type 2a
C. Type 2b
D. All of the above

Answer 7

A. Type 1 fibers (Escourolle, p. 279)

Question 8

T/F: Type 1 fibers stain strongly with NADH-TR & SDH whereas type 2 fibers are relatively weakly stained
A. True
B. False

Answer 8

A. True (Escourolle p. 280)

Question 9

At what age do muscle fibers take on a polygonal cross-sectional shape histologically?
A. 3-6 months
B. 3-6 years
D. 6-8 months
E. 6-8 years

Answer 9

B. 3-6 years (Escourolle p. 281)

Question 10

Small beaded eosinophilic inclusions seen in motor neurons in motor neuron disease
A. Marinesco bodies
B. Hirano bodies
C. Lafora bodies
D. Bunina bodies

Answer 10

D. Bunina bodies (Ellison p. 9)

Question 11

Brightly eosinophilic inclusions that develop in astrocytes, seen in longstanding reactive gliosis, pilocytic astrocytoma, Alexander’s disease, & giant axonal neuropathy
A. Rosenthal fibers
B. Granular bodies
C. Corpora amylacea
D. Spheroids

Answer 11

A. Rosenthal fibers (Ellison’s p. 13)

Question 12

Astrocytes with enlarged vesicular nucleus with marginated chromatin, scanty cytoplasm, seen in liver failure
A. Alzheimer type I
B. Alzheimer type II
C. Alzheimer type III
D. Alzheimer type IV

Answer 12

B. Alzheimer type II (Ellison’s p. 15)

Question 13

Tau inclusions called coiled bodies, which occur in the perinuclear oligodendrocyte cytoplasm, are seen in which 3 diseases?

Answer 13

1. PSP
2. CBD
3. FTDP-17
   (Ellison’s p. 19)

Question 14

Glial cytoplasmic inclusions, which are curved, filamentous, or flame-shaped oligodendrocyte inclusions are seen in what disease?
A. PSP
B. CBD
C. FTDP-17
D. MSA

Answer 14

D. MSA (Ellison’s p. 19)