White blood cells Flashcards
What is the common origin of all blood cells?
Mulipotent haematopoietic stem cell aka haemocytoblast
What does the haemocytoblast differentiate to?
Common myeloid progenitor
Common lymphoid progenitor
What does the common myeloid progenitor differentiate to>
Megakaryocyte
Erythrocyte
Mast cell
Myeloblast
What does a myeloblast differentiate to?
Basophil
Neutrophil
Eosinophil
Monocyte
What does the common lymphoid progenitor differentiate to?
Natural killer cell
Small lymphocyte –> T and B lymphocyte
What are the types of phagocytic cells?
Neutrophils
Monocytes
What part of the immune system are neutrophils contained?
Innate
What is the function of neutrophils?
Ingest and destroy pathogens
Phagocytosis
What is the lifespan of neutrophils?
Short, ~1day
How are neutrophils regulated?
Immune responses
What are the types of monocytes?
MAcrophages
Dendritic cells
What is the function of the monocytes?
Ohagocytosis
Antigen presentation
Cytokine production
What are the types of lymphoid cells?
B lymphocytes
T lymohocytes
Natural killer cells
What are the types of T cell?
T helper cells
Cytotoxic T cells
What are the types of B cell?
Plasma cell
Memory cell
Where do lymphocytes get produced and mature?
Produced in bone marrow
T mature in thymus
B mature in bone marrow
What are the functions of platelets?
Haemostasis
Where is regulation of platelet production?
Liver
What is the lifespan of platelets?
7 days
What is and causes thrombocytopenia?
Low platelet count
Cause- decreased production, increased consumption, medication induced, other
What causes neutrophilia?
Infection
Inflammation
What causes neutropenia?
Decreased production- drugs, marrow failure
Increased consumption- sepsis, autoimmune
Altered function
What causes lymphocytosis?
Infectious mononucleosis
Pertussus
What causes lymphopenia?
Usually post viral