What kinds of transition state changes might occur in the substrate that would make a reaction proceed more rapidly?

Question 1

The enzyme might put “_____” on a bond and thereby promote bond breakage, as in the example of _____

Answer 1

stress

sucrase

Question 2

The _____ enzyme catalyzes the hydrolysis of sucrose into ____ and _____

Answer 2

sucrase

glucose and fructose

Question 3

The formation of the enzyme-substrate complex results in a change in the shape of the

Answer 3

enzyme

Question 4

This, in turn, may stretch or distort the bond between glucose and fructose, _____ the bond and allowing it to be broken much more _____ than in the absence of the enzyme

Answer 4

weakening

easily

Question 5

An enzyme may facilitate a reaction by bringing two reactants ____ to one another and in the ____ orientation for reaction to occur.

Answer 5

close

proper

Question 6

The enzyme can bring the two molecules close together in the correct ____ forming the _______ and greatly _____ the reaction.

Answer 6

alignment
transition state
speeding up

Question 7

The active site of an enzyme may modify the ____ of the microenvironment surrounding the substrate.

Answer 7

pH

Question 8

For instance, it may serve as a donor or an acceptor of

Answer 8

H+

Question 9

This would cause a change in the pH in the vicinity of the substrate without

Answer 9

disturbing the normal pH elsewhere in the cell.