Western Review Course Tidbits Flashcards
what % of those with ASD will have ID
35%
what % of those with ASD will develop seizures in childhood or adolescence
20%
what is the heritability of ASD
about 90%
what is the sibling recurrence rate in ASD
about 5-10%
what % of those with ASD also meet criteria for ADHD
50% at least
should we use SSRIs to treat repetitive/ritualistic behaviour in ASD
cochrane review–> wasnt enough evidence to warrant general use for this
name two medications that have shown efficacy in treating repetitive behaviours in those with ASD
risperidone and haloperidol
haldol–> also helps with social withdrawal
what generally occurs during phase I metabolism
oxidation, reduction, hydrolysis
what generally occurs during phase II metabolism
conjugation, acetylation
list 4 medications that are exclusively renally excreted
lithium
gabapentin
pregabalin
topirmate
which 4 drugs commonly used in psychiatry inhibit 2D6 and thus increase the levels ofmany drugs
buproprion
fluoxetine
duloxetine
paroxetine
would increase levels of: risperidone, olanzapine, vortioxetine, TCAs, beta blockers + reduces codeine effects
why is fluvoxamine such a pain
is a pan-CYP inhibitor basically
especially 1A2–> will increase levels of clozapine and olanzapine
what is the relationship bwteen valproate and lamotrigine
should you add lamotrigine to valproate or valproate to lamotrigine
avoid combining but if you have to combine, always add lamotrigine to valproat and not the other way around
start at half the lamotrigine dose
should you add lamotrigine to valproate or valproate to lamotrigine
avoid combining but if you have to combine, always add lamotrigine to valproat and not the other way around
start at half the lamotrigine dose
