Week one formative Flashcards
Where is vitamin D metabolism carried out?
Keratinocytes
Where is energy stored in the skin?
Subcutaneous fat
Where are langerhan cells formed?
In the bone marrow
In what layer of the skin are highly metababolically active small cuboidal cells found?
Basal layer
In what layer of the skin are odland bodies found?
Granular layer
In what layer of the skin are corneocytes found?
Keratin layer
In what layer of the skin are polyhedral cells will lots of desmosomes found?
Prickle cell layer
What is the function of pacinial corpuscles?
Pressure sensation
What is the function of meissner’s corpuscles?
Vibration sensation
How do topical steroids work on the skin?
They are liphophilic allowing passive diffusion across the plasma membrane where they combine will cell receptors and bind to steroid responsive elements in DNA
What are the effects of steroid treatment?
Anti-proliferatives
Anti-inflammatory
Vasoconstrictive
What will affect absoprtion of topical treatments?
Skin thickness Skin state Occlusion Vehicle use Drug concentration
What is importnat to maintain good circulation in the lower limb?
Venous valves
Pulse pressure
Muscle pump
What is the function of adhesin?
Enables binding of an organism to host tissue
What is the function of impedin?
Enables organism to avoid host defences
What is the function of aggressin?
Damages host directly
What is the function of invasin?
Induces damage to host indirectly
What is the function of invasin?
Enables the organism to invade a host tissue
What enzyme deficiency mediates acute intermittent porphyria?
Impaired function of porphobilinogen deaminase
What is present in the dermis?
Fibroblasts
Lymphatics
Ground substance
What is present in the dermo-epidermal junction?
Hemi-desomosomes
When do skin glands develop in a foetus?
6 month gestation
What type of hypersensitivity in direct cell killing?
Type 2
What type of hypersensitivity is immune complex mediated?
Type 3
What is the mediator for type 1 hypersensitivity?
IgE
What is the mediator for type 2 and 3 hypersensitivity?
IgM and IgG
What is the mediator for type 4 hypersensitivity?
Th1 cells
What are the symptoms of erythropoietic protoporphyria?
Presents in early childhood with dicomfort, itch or tingling when sun exposed
What is the biochemical pathway of erythropoietic protoporphyria?
Build-up of protoporphyrin 9 due to lack of ferrochelatase
What are the 3 phases of hair growth?
Anagen - growing
Catagen - involuting phase
Telogen - resting phase
What is the definition of prevalence?
The proportion of a population affected by a disease at any given time
