Week 9: Drug Abuse Flashcards
The “Rat Park” experiments, by Bruce Alexander, demonstrated that addiction rates are powerfully determined by
A. Social and environmental factors B. Pharmacological factors C. Genetic factors D. Learning factors
Social and environmental factors
Drug vaccines, such as NicVax, are probably most effective at
A. Easing withdrawal symptoms B. Treating short-term addiction C. Preventing addiction D. Treating long-term addiction
Preventing addiction
What proportion of patients addicted to alcohol/drugs have also been diagnosed with a psychiatric disease?
A. ⅓
B. ⅔
C. ½
D. ¼
⅓
The use of Chantix to help people stop using nicotine is an example of what kind of pharmaceutical approach?
A. Withdrawal maintenance B. Agonist substitution C. Partial agonist substitution D. Antagonist administration
Partial agonist substitution
The mesolimbic pathways begins in the VTA and terminates in the
A. Nucleus accumbens, hippocampus, and prefrontal cortex
B. Amygdala, hippocampus, and prefrontal cortex
C. Nucleus accumbens, amygdala, and hippocampus
D. Nucleus accumbens, amygdala, and prefrontal cortex
Nucleus accumbens, amygdala, and prefrontal cortex
The use of clonidine to treat alcohol/opiate addiction is an example of which pharmaceutical treatment strategy?
A. Withdrawal maintenance
B. agonist substitution
C. partial agonist substitution
D. antagonist administration
Withdrawal maintenance
The biological definition of addiction states that addictive substances
A. Increase 5-HT levels in the CNS B. Decrease DA release in the frontal lobes C. Activate the VTA pathway D. Are pleasurable
Activate the VTA pathway
Administration of Methadone to heroin addicts is an example of
A. Withdrawal maintenance B. Agonist substitution C. Partial agonist substitution D. Antagonist administration
Agonist substitution
The drugs used in agonist substitution protocols tend be chosen because they
A. Have longer half-lives B. Work on different NT systems C. Are less efficacious D. Are more potent
Have longer half-lives
Using naltrexone to treat alcohol abuse is an example of which pharmaceutical approach?
A. Partial agonist substitution B. Agonist substitution C. Antagonist administration D. Withdrawal maintenance
Antagonist administration
Relapse is most likely induced by all of the following EXCEPT
A. Decreased sensitivity of DA receptors
B. reexperience with the drug
C. stress
D. exposure to conditioned drug cue
Decreased sensitivity of DA receptors
The reason antagonist administration strategies are often unsuccessful is due to
A. Development of tolerance to the antagonist B. Patient non-compliance C. Toxicity issues D. Safety issues
Patient non-compliance
The following are all advantages of the partial-agonist substitution pharmacological approach EXCEPT:
A. Blocks pleasurable effects of the drug
B. does not induce abuse
C. reduces cravings
D. decreases withdrawal symptoms
Blocks pleasurable effects of the drug
Stress impacts addiction in all of the following ways EXCEPT
A. Stress and addiction share similar neurobiological pathways B. Stress increases the likelihood of substance abuse C. Stress increases the likelihood of craving and relapse D. Stress increases the efficacy of addictive drugs
Stress increases the efficacy of addictive drugs
The mesolimbic pathway is made up of neurons that produce
A. Norepinephrine B. Dopamine C. Endorphins D. Serotonin
Dopamine
