Quiz 10: Pain Medications Flashcards

1
Q

Ibuprofen is an especially good choice for

A. Nursing mothers
B. patients on blood-thinning meds
C. patients with peptic ulcers
D. patients with renal failure

A

Nursing mothers

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2
Q

Compared to morphine, heroin is

A

More lipid soluble

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3
Q

Suboxone is the combination of buprenorphine and

A. Naltrexone 
B. Sibutramine 
C. Naloxone 
D. Acetaminophen
A

Naloxone

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4
Q

Which of the following nuclei is NOT a part of the descending pain modification system?

A

Nucleus basalts

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5
Q

To which receptor does oxycodone bind the most?

A. GABA
B. Delta opioid 
C. Mu opioid 
D. Histamine
A

Mu opioid

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6
Q

Acetaminophen is not recommended for people who have

A. Rheumatoid arthritis
B. fever
C. chronic pain
D. acute pain

A

Rheumatoid arthritis

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7
Q

What is the pharmacodynamic action of aspirin?

A. Selective COX-1 inhibitor
B. Selective COX-2 inhibitor
C. Selective COX-1 agonist
D. Non-selective COX inhibitor

A

Non-selective COX inhibitor

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8
Q

The cell bodies of nociceptors are found in the

A. dorsal root ganglion of the spinal cord
B. the ventral root ganglion of the spinal cord
C. dorsal horns of the spinal cord
D. the ventral horns of the spinal cord.

A

Dorsal root ganglion of the spinal cord

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9
Q

In addition to stimulating mu opioid receptors, tapentadol also

A. Blocks the NET
B. stimulates DA response
C. blocks the SERT
D. stimulates 5-HT receptors

A

Blocks the NET

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10
Q

What is the primary indication for acetaminophen?

A. Depression 
B. Analgesia and antipyresis 
C. GAD and OCD
D. Bipolar disorder
A

Analgesia and antipyresis

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11
Q

Which of the following drugs is a good choice for “poor metabolizers” or patients with compromised liver function?

A. Propoxyphene 
B. Meperidine 
C. Tapentadol 
D. Oxymorphone
A

Propoxyphene

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12
Q

The metabolism of codeine into morphine can be blocked by

A. SSRIs
B. benzodiazepines
C. antipsychotics
D. lithium

A

SSRIs

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13
Q

Dull, diffuse pain signals are transmitted via __________ fibers.

A. A-delta 
B. C-delta 
C. C 
D. A-beta
A

C

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14
Q

Which of the orders below describes the level of opiate potency, from lowest to highest?

A. Opium, heroin, morphine 
B. Opium, morphine, heroin
C. Heroin, morphine, opium
D. Morphine, heroin, opium
A

Opium, morphine, heroin

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15
Q

Combining acetaminophen with alcohol is dangerous because it can result in

A. Hepatotoxicity 
B. Psychosis 
C. Pulmonary embolism 
D. Tachycardia
A

Hepatotoxicity

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16
Q

Aside from analgesia, what is the other primary indication for hydrocodone?

A. Sleep aid 
B. Muscle relaxant 
C. Cough suppressant 
D. Hypotension
A

Cough suppressant

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17
Q

Inhibition of COX-1 results in

A. Antipyresis
B. Analgesia 
C. Upset stomach 
D. Reduced inflammation
A

Upset stomach

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18
Q

Fentanyl is at least ____ times more potent than morphine

A. 40
B. 20
C. 60
D. 80

A

80

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19
Q

What is the #1 cause of acute liver failure?

A

Taking too much acetaminophen

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20
Q

True/False: You can take Tylenol for a hangover

A

FALSE

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21
Q

True/False: ibuprofen (Advil) is found in breast milk

22
Q

True/False: concurrent administration of ketorolac (Toradol) with morphine can decrease morphine requirement

23
Q

True/False: Indomethin (Indocin) has an increased side-effect liability

24
Q

True/False: Sulindac (Clinoril) causes less GI upset than indomethin

25
What kind of preparations are available for diclofenac (Voltaren)?
delayed release, topical, and skin patch
26
True/false: nabumetone (Relafen) is recommended for long-term treatment
TRUE
27
True/False: Celecoxib (celebrex) has no cardioprotective effects
True, in fact it can actually increase risk.
28
What are some common side effects of morphine?
respiratory depression, pupillary constriction, constipation, decreased sex drive/fertility problems, itching
29
______ is metabolized to morphine (CYP 2D6). SSRIs can block this transformation
Codeine
30
_____ is often mixed with acetaminophen (i.e., Vicodin, Norco)
31
Hydrocodone is used for ________
mild-moderate pain, cough suppression
32
___ is one of the most frequently abused prescription drugs in the USA
hydrocodone
33
___ causes increased lipid solubility
heroin
34
___ is 3x more potent than morphine
heroin
35
___ has 6-10x the potency of morphine
hydromorphone/oxymorphone
36
___ and ___ may inhibit the effects of hydromorphone/oxymorphone
antihistamines, MAOIs
37
___ has greater euphoric effects than morphine
meperidine
38
methadone has a half life of ___
24-36 hrs
39
levo-alpha acetylmaethadol has a half life of ___
2.5 days
40
levo-alpha acetylmaethadol has an increased risk of ____
cardiac effects
41
___has a lower risk of dependence
propoxyphene
42
___ is a good choice for poor metabolizers
propoxyphene
43
___ has 80-500x the potency of morphine
fentanyl
44
___ is used for opioid dependency through suppression of craving and decreased euphoria.
buprenorphine
45
___ is a a combo of buprenorphine and naloxone. It treats opioid dependency without risk of abuse.
suboxone
46
___ is a Mu agonist and blocks NET
tapentadol
47
pentazocine has a __ risk of dependence or respiratory depression
LOW
48
___ reverses respiratory depression caused by opiate OD. It lasts longer than naloxone
naloxone
49
naltrexone is used to treat ___
opioid and alcohol dependence
50
methylnaltrexone/alvimopan does not cross the blood brain barrier, it only has peripheral effects
TRUE