Week 9 - CVD antiplatelet

Question 1

Describe what haemostasis is?

Answer 1

The stopping of blood loss caused by damaged blood vessels

Question 2

Define thrombosis and describe the stages of atherosclerosis

Answer 2

Thrombosis - pathological formation of a clot in the vasculature without the presence of bleeding

Atherosclerosis-

First stage - Biuld of a fatty streak made up of ( LDL) cholestrol in inner lining whilst monocytes and leukocytes migrate to endithelial layer and adhere to it along side with pro inflammatory chemokines on the endo cell surface. —–> Biuld up of LDL leads to cell oxidation

Second Stage - Endothelial cell activation - T cells and monocytes accumulate which then differentiate into macrophages which then

T cell and macrophages are activated and accumulate and smooth muscle cells migrate to the area