Drugs used in inflammatory diseases - NSAIDs

Question 1

general info

Paracetemol - Indication and considerations

Answer 1

1. Main use as antioyretic ( NO significant anti inflammatory effect)
2. Caution should be taken for Inadvertent overdose
   * Check for duplicate prescribing

Question 2

What are the special patient groups for Paracetemol?

Answer 2

• Body weight >50kg
• Children
• Liver impairment ( or those at risk of hepatic impairment )

Question 3

In what cases (patient groups) is paracetemol the preferred analgesic over NSAIDs?

Answer 3

• Elderly ( weight dependant)
• Patients with GI issues, hypertension, CVD, renal impairment ( side effects of NSAIDs)
• Patients on medications which interact with NSAIDs i.e warfarin

Question 4

What is the dosage of aspirin when being used as an antiplatelet and an analgesic?

Answer 4

1**. Antiplatelet **- 75 mg – 300 mg daily (loading dose dependent on indication)
* No anti-inflammatory effect

2. * Analgesic – Standard oral dose: 300-900 mg every 4 – 6 hours when required
   (max. 4 g per day)
   * Rarely used now in inflammatory conditions–

Question 5

What are the special patient groups for Aspirin?

Answer 5

• Contraindicated in children under 16 (except when specifically indicated - Kawasaki
  syndrome)
• Contraindicated in patients with: previous or active peptic ulcerations, bleeding
  disorders, severe cardiac failure, previous hypersensitivity to aspirin or NSAID
• Elderly
• Caution in patients with: asthma222