Week 8 Flashcards
how is immunity developed?
- as a response to protect the body from attacks by foreign antigens, typically proteins
what are different kinds of immunity? (4)
- innate (natural/native)
- acquired
- resistance
- herd immunity (community)
what is innate immunity? what type of response does it provide?
- immunity present at birth
- provides a nonspecific response
what is acquired immunity?
- immunity protection gained after birth
what is active acquired immunity
- develops after the introduction of a foreign antigen resulting in the formation of antibodies or sensitized T lymphocytes
what is artifical active acquired immunity
- exposure due to immunization
what is passive acquired immunity
- intro of preformed antibodies such as transfusion of antibodies
- or passed from mother to fetus
what is resistance immunity
- the ability to limit pathogen burden
what is herd immunity
- the resistance of a group to invasion and spread of an infectious agent, based on high proportion of individual members of the group being resistant to infection
- ie. if a sufficient proportion of a group is vaccinated, both vaccinated and unvaccinated are protected from the disease
for the guideline “immunization services should be readily available”, how is this relevant to CHN? to acute care nurse?
- CHN: decrease barriers (ex. opening hours)
- acute care nurse: give vaccines at access points to care
for the guideline “vaccine providers should facilitate timely receipt of vaccine & eliminate unnecessary prepreqs to the receipt of vaccines”, how is this relevant to CHN? to acute care nurse?
- CHN: appointment only is a barrier
- ACN: no written order should be necessary
for the guideline “vaccine providers should use all clinical opportunities to screen for needed vaccines and to administer all vaccine doses for which a vaccine recipient is eligible at the time of each visit”, how is this relevant to CHN? to acute care nurse?
- CHN: always go over vaccine status (ie. during home visits)
- ACN: we should be allowed to check if someone is up to date on vaccination in clinical settings
for the guideline “vaccine providers should communicate current knowledge about immunization using an evidence based approach”, how is this relevant to CHN? to acute care nurse?
- CHN & ACN: evidence informed communication
for the guideline “vaccine providers should inform vaccine recipients and parents in specific terms about the risks and benefits of vaccines that they or their children are to receive”, how is this relevant to CHN? to acute care nurse?
- CHN and ACN: evidence informed communication
for the guideline “vaccine providers should ensure that all vaccinations are accurately and completed recorded”, how is this relevant to CHN? to acute care nurse?
- CHN and ACN: record appropriately
for the guideline “vaccine providers should maintain easily retriveable summaries of immunization records to facilitate age-appropriate vaccination”, how is this relevant to CHN? to acute care nurse?
- CHN and ACN: document
for the guideline “vaccine providers should report clinically significant adverse events following immunization promptly, accurately, and completely”, how is this relevant to CHN? to acute care nurse?
- CHN: report adverse events promptly, analyze, and evaluate
- ACN: report adverse events promptly
for the guideline “vaccine providers should report all cases of vaccine preventable diseases as required under provincial or territorial legislation”, how is this relevant to CHN? to acute care nurse?
- CHN : report all cases, keep an eye on epidemiological data, advocate for vaccination services
- ACN: report
for the guideline “vaccine providers should adhere to appropriate procedures for the storage and handling of immunizing agents”, how is this relevant to CHN? to acute care nurse?
- CHN: keep eye on storage chain
- ACN: check lot number, etc.
for the guideline “vaccine providers should maintain up to date, easily retrievable immunization protocols at all locations where vaccines are administered”, how is this relevant to CHN? to acute care nurse?
- CHN: create protocols, know where they are
- ACN: know where protocols are
for the guideline “vaccine providers should be properly trained and maintain ongoing education regarding current immunization recommendations”, how is this relevant to CHN? to acute care nurse?
- CHN: train and keep up to date
- ACN: train
for the guideline “immunization errors and immunization related incidents should be reported by vaccine providers to their local jurisdiction”, how is this relevant to CHN? to acute care nurse?
- CHN: report errors, analyze
- ACN: report errors
for the guideline “vaccine providers should operate an immunization tracking system”, how is this relevant to CHN? to acute care nurse?
- CHN: track
for the guideline “audits should be conducted in all immunization services to assess the quality of immunization records and the degree of immunization coverage “, how is this relevant to CHN? to acute care nurse?
- CHN: audit
what is important to overcome vaccine hesitancy
-communication
vaccine hesitancy can be caused by… (5)
- lack of understanding
- conflicting info
- mistrust of source of info
- perceived risks of serious adverse events
- lack of appreciation of the severity and incidence of the disease and sociocultural beliefs
how can communication help overcome vaccine hesitancy? (4)
- adopt a vaccine recipient-centered approach
- respect differences of opinion about immunization
- represent the risk and benefits of vaccines fairly & openly
- clearly communicate current knowledge using an evidence-based approach
what are general principles of vaccine interchangeability
- when possible, use the same manufacturer of all doses in a series
- vaccines are interchangable when authorized for the same indications, with similar schedule, same population, comparable type & quality, similar in terms of safety, reactogenicity, immunogenicity, and efficacy
should aspiration be done with immunizations?
- contraindicated as it can be painful & there are no large blood vessels at the recommended immunization sites
how are vaccines handled/stored?
- cold chain during transport, stroage, and handling (this is monitored)
age recommendations for vaccines are based on…
- when the risk of the disease is the highest and for which vaccine safety & efficacy has been demonstrated
vaccine doses given before the recommended age may lead to…
- less than optimal immune response
can more than one vaccine be given at the same time?
- yes , especially when these vaccines are inactivated
- with site rotation, live vaccines can be given together with other injection vaccines
if live vaccines are not given at the same time, live vaccines should be given at least __ weeks apart
- 4 weeks apart
what has been found to interfere w effectiveness of parental live vaccines?
- blood products
- human immune globulin
vaccines should be adminstered ____ before admin of blood products & human immune globulin
14 days prior , but preferably months
who recommends vaccine schedules?
- canada recommends but provinces and territories can determent the best schedule for their region
describe the prep of single dose vials
- can be reconstituted or drawn up immediately before admin
describe the prep of multidose vials
- can be reconstituted & marked with date & time
vaccines should be stored at what temps?
+2 to +8 degrees
- and based on manufacturer guidelines
when should vaccines be removed from fridge?
- only when using
when are vaccines discarded?
- discarded within a manufacturer set time frame
what does a missed appointment/interrupted vaccine doses mean?
- in general, does not require restarting of the series
- schedules can be delayed or accelerated and full immunization can still be achieved
what does CARD stand for?
Comfort
Ask
Relax
Distract
what is CARD?
- an evidence based framework that teaches how to prepare for vaccination
what are the benefits of CARD (3)
- reduces stress-related reactions (such as fear, pain, dizziness, and fainting during vaccination)
- improves the vaccination experience for people receiving a vaccine and for those who support them (ex. parents, HCP, educators)
- teaches lifelong coping skills that can be used for other stressful situations
what organism causes diphtheria?
cornebacterium diptheria
what is the mode of transmission for diphtheria
- direct contact
- indirect contact
what is the incubation period of diphtheria
- 2-5 days
what is the communicability of diphtheria for both treated & untreated
- untreated = 2 weeks to several months
- treated = 2-4 weeks
what is the reservoir for diphtheria
human carriers
what is the clinical presentation of diphtheria (6)
- greyish spots on tonsils
- sore throat
- enlarged lymph nodes
- swelling & edema of neck
- fever
- difficulty breathing
when does immunization occur for diphtheria (6)
- 2m
- 3m
- 6m
- 18m
- 4-6 yo
- every 10 years
what are complications of diphtheria (4)
- damage to heart muscles
- breathing problems
- paralysis
- 1 in 10 die (5-10%) case fatality rate
what are control measures for diphtheria (3)
- immunization
- abx
- isolation and disinfection of contact articles
what organism causes poliomyelitis?
- poliovirus, types 1, 2, and 3
what is the mode of transmission for poliomyelitis (3)
- fecal-oral contact
- contaminated food or water
- pharyngeal (during epidemics) (salivia)
what is the incubation period of poliomyelitis
3-21 days
what is the communicability for poliomyelitis
- 7-10 days after onset of symptoms –> up to 6 weeks or longer
what is the reservoir for poliomyelitis
- human carriers
what is the clinical presentation of poliomyelitis (7)
- fever
- sore throat
- drowsiness
- headache
- NV
- stiffness of neck & back, with or without flaccid paralysis
- muscle aches
what % of people are asymptomatic with poliomyelitis? minor illness for few days? viral mengingitis? flaccid paralysis?
- 90% asymptomatic
- 4-8% minor illness for few days
- 1-5% viral meningitis
- 1% flaccid paralysis
what are complications of poliomyelitis (3)
- paralysis
- death
- post-polio syndrome
what are control measures for poliomyelitis (2)
- vaccination
- isolation & disinfection of contact articles
what is the global goal for poliomyelitis
- eradication of polio
where is poliomyelitis eradicted?
- in western hemisphere in 1994, but not worldwide
what factors contributed to the re-emergence of polio in newyork
- pandemic related declines in childhood vaccinations (missed appts, delayed appts)
- vaccine hesitancy and misinformation (reinforced thru pandemic, strong anti-vaccine sentiment)
what are the 2 types of polio vaccine
- inactivated (injectable)
- oral polio vaccine (oral drops)
the inactivated polio vaccine is the vaccine of choice for…. and protects against…
- choice for routine immunization in polio-free countries
- protects against three strains of polio (1,2, and 3)
describe the production of antibodies with the inactivated polio vaccine
- produced in blood stream
describe the protection offerred by the inactivated polio vaccine
- does not fully block polioviruses from infecting the gut = people inoculated with IPV can still transmit polio
- protects the individual but not the community
what is the main tool in the global eradication of polio
- oral polio vaccine
what kind of vaccine is the oral polio vaccine
- live but weakened strains of polio (1,2,3)
describe how the oral polio vaccine works
- vaccine virus replicated and stimulates immunity in both gut & blood
the oral polio vaccine protects…
- the individual and community
what is one con with the oral polio vaccine
- cases of vaccine derived polio emerged in developing world (type 2)
- in 2016, bOPV (only strain 1 and 3) introduced… not well coordinated consequently, vaccine derived polio surged (type 2)
describe the “polio perfect storm” in new york (3)
- rockland county immunization rates = 60%
- IPV given = may allow greater transmission of virus
- vaccine derived poliovirus exposure to unvaccinated individual
describe the new york response to polio (4)
- one case signals many infections = declared “state of emergency”
- vaccination efforts in affected communities
- enhanced surveillance (waste water, reporting all vaccines given)
- US added to list of countries w circulating vaccine derived poliovirus
what organism causes pertusis
- bacteria bordetella pertussis
what is the mode of transmission of pertussis
- direct contact w resp secretions
what is the incubation period of pertussis
- 6-20 days, usually 7-10 days
what is the communicability of pertussis
- to 3 weeks after onset of paroxysmal cough, if not treated
what is the reservoir of pertussis
- humans
what is the clinical presentation of pertussis (4)
- begins with low grade fever
- runny nose
- mild cough (7-10 days)
- progresses to violent coughing & whooping which lasts up to 10 weeks
what are complications of pertussis (5)
- apnea
- seizures
- pneumonia
- 1-3 deaths in Canada yearly
- 1/400 deaths in infancy
when does immunization of pertussis occur (5)
- 2m
- 4m
- 6m
- 18m
- 14-16y
what are control measures of pertussis (3)
- immunization
- exclusion 5 days after treatment with antibiotics
- treatment of close contacts
what organism causes tetanus
- bacteria clostridium tetani
what is the mode of transmission of tetanus
- bacterial spores thru contaminated puncture wounds, burns, cuts
what is the incubation period of tetanus
- 3-21 days, average 10
what is the communicability of tetanus
- not transmitted person to person
what is the reservoir of tetanus
- soil or fornites contaminated with soil/feces
the clinical presentation of tetanus (3)
- muscle rigidity & spasm
- lockjaw
- respiratory and largyngeal spasm