Week 7 (Suppository) Flashcards
1
Q
When are suppositories used?
A
Alternative for NPO patients, avoiding IV access
2
Q
Properties of an Ideal Suppository Base
A
- Chemical and physically stable
- Nonreactive and stable with drugs and auxillary agents
- Aesthetically pleasing
- Melt/dissolve in the intended body cavity
- Nontoxic/nonirritating to tissues
- Nonbinding with drugs
- Viscous enough for drug suspension, but thin enough to pour into mold
- Shrinks on cooling to easily release from molds
3
Q
Types of Bases for Suppositories (2)
A
- Oleaginous, fatty bases (cocoa butter, fattibase)
- Water soluble/miscible bases (polyethylene glycol)
4
Q
Density Factor (DF)
A
Ratio of a unit mass of drug powder to the amount of suppository base displaced by the powder (published or can be calculated)
Used to determine how much base will be displaced by a drug
- Not mold specific
- Base specific, drug specific
5
Q
When do you use density factors?
A
- When a drug has a quantity dose and is being used for a systemic effect
- When quantity of drug is relatively significant portion of the dosage form
- When density difference exists between the base and the drug (if DF for a drug in a base is 1, density displacement calculation not needed because equal displacement of drug for base)
