Week 3 (Suspensions)

Question 1

Advantages of Oral Liquid Dosage Forms (2)

Answer 1

• Can accommodate precise, nonstandard dosing
• Easy to administer

Question 2

Disadvantages of Oral Liquid Dosage Forms

Answer 2

• Drug often less stable, shorter beyond-use date
• Difficult to mask unpleasant smells or tastes
• Specific storage conditions (might need refrigeration)
• Specific storage conditions
• Measuring devices, measuring abilities, variability in standard concentrations

Question 3

Properties of Suspensions

Answer 3

Fine, uniform-sized particles that are uniformly dispersed in the liquid vehicle and have slow settling of particles

Question 4

How do you improve properties of suspensions?

Answer 4

1. Decrease particle size/diameter
2. Decrease the difference in the density between solid and liquid (increase density of the liquid by using sucrose, glycerin, or sorbitol)
3. Increase the viscosity of the suspending liquid (by using a viscosity-inducing agent like acacia and methylcellulose)

Question 5

Suspension Compounding Procedure (7)

Answer 5

1. Add powder form of drug into a mortar
2. Add enough glycerin so that a uniform paste forms
3. Add in simple syrup while mixing
4. Put this content into a calibrated bottle (using the simple syrup to help transfer everything)
5. Add simple syrup to the needed volume (calibrated line)
6. Add label and auxillary stickers (shake well and refrigerate)
7. Dispense