Week 7 Flashcards
What is inflammation?/
A vascular and cellular response to trauma.
What is the purpose of inflammation?
Its purpose is to intiate the healing of the injured tissue. It’s the body’s attempt to dispose of foregin material and dying tissue so that tissue repair can occur
What does inflammation do?
Protects the body by localising and removing the injuring agent
What are the 5 signs of inflammation?
Redness, increased heat, swelling, pain and loss of function
How long does phase 1 of the inflammatory response last?
0-72 hours
What happens during phase 1 infammatory response?
Tissue damage intiates inflammation, intial brief vasoconstriction then vasodilation for the rest of inflam response, increased cell permeability causes edema, fibrin clot formed, WBC go to area to get rid of waste/debris and infection.
What happens up to 10 mins post injury?
Intial vasoconstriction, reduced blood loss at injury site
What happens 10+ mins post injury?
vasodialtion, increased blood to injury site
What happens during the clotting?
Blood becomes more viscous, cells combine with fibrin to cause a clot, platelet reaction occurs
What happens at the cellular stage, 1 hour post injury?
WBC (leukocytes, neutrophils and macrophages) go to injury site. WBC adhere to vessel wall then squeeze through wall into damaged tissue, chemical signals trigger WBCs to enter damaged tissue (chemotaxis) this leads to phagocytosis where WBCs engulf debris and bacteria at injury site
How long does phase 2: proliferation last?
12 hours-6 weeks
What happens during phase 2: proliferation?
Angiogenesis (growth of new blood cells), fibroplasia (process of generating collagen tissue via fibroplast activity), changes in cellular activity means reinforcement of new connective tissue and formation of grandulation tissue
What is the timeframe of collagen synthesis?
12 hours-6 weeks (average 3 weeks)
What are type 3 collagen fibres?
Smaller fibres with less cross linking and highly disorganised (fibrous scar tissue)
What are type 1 collagen fibres?
Associated with muscular tissue (larger and stronger fibres)
