Week 7 Flashcards

1
Q

unique charcteristics of skeletal Muscle

A

Attach to bones & produce movement

Voluntary, Striated (“striped”), tubular, multi-nucleate

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2
Q

unique charcteristics of cardiac muscle

A

Only in heart

Involuntary, Striated, branched, uni-nucleate

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3
Q

unique charcteristics of smooth muscle

A

Gut muscle, blood vessels

Involuntary, Non-striated, spindle-shaped, uni-nucleate

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4
Q

general muscle charcteristics

A
  • Excitability
  • Ability to respond to stimulation
  • Contractility
  • Ability to shorten forcefully
  • Extensibility
  • Ability to stretch & still contract
  • Elasticity
  • Ability to resume resting length after contraction
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5
Q

functions of muscle

A
-Produce movement
	Locomotion: skeletal
	Blood pressure: --cardiac Propulsion: smooth
-Maintain body positions and posture
-Support soft tissues
-Maintain body temperature
-Store nutrients
-Valves/Sphincters
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6
Q

What is Fasica

A

connective tissue that attaches the hypodermis to the muscle beneath
Fascia lies over the epimysium

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7
Q

what are the three CT layers associated with muscle

A

Epimysium
perimysium
endomysium

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8
Q

epimysium

A

CT that covers the entire muscle

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9
Q

perimysium

A

CT that covers the fascicles

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10
Q

fascicles

A

bundles of muscle fiber cells

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11
Q

endomysium

A

surrounds an individual muscle cell

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12
Q

what is the purpose of connective tissue in the muscle

A

Together, the three muscle connective tissue layers strengthen muscles (keep muscles from bursting under pressure) and come together to form tendons (attach muscle to bone) and aponeruoses (a tendon sheet)

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13
Q

levels of organization of muscle

A

fascicle, muscle cell, myofibril, sarcomeres, myofilaments

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14
Q

muscle cell

A

muscle fiber- covered by connective tissue endomysium, its cell membrane is called sarcolemma

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15
Q

sarcolemma

A

the fine transparent tubular sheath that envelops the fibers of skeletal muscle cells

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16
Q

myofibril

A

cylindrical structures made of repeating sarcomeres, 100s-1000s of myofibers in a muscle cell

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17
Q

sarcomere

A

the contractile unit of muscle, composed of myofilaments made of contractile filaments (~10,000 per myofibril)

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18
Q

myofilaments

A

3 kinds of filament make up the sarcomere, thick (myosin) thin (actin) elastic.

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19
Q

what are elastic filaments made up of

A

titin

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20
Q

what are myofibrils covered in?

A

sarcoplasmic recticulum

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21
Q

what is sarcoplasmic retculum

A

a specialized endoplasmic reticulum. Its job is to release calcium to induce muscle contraction

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22
Q

what are T tubules?

A

they are continuous with in the sarcolemma, and transmit the action potential throughout the muscle cell.

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23
Q

study the parts of the sarcomeres

A

STUDY IT

24
Q

What do actin filaments do

A

actin filaments slide pass myosin filaments during muscle contraction.

25
Q

what do myosin filaments do?

A

Myosin molecule heads bind the actin to keep the muscle from sliding backwards. Myosin heads will bind and release multiple times during a contraction, to move the thin filaments

26
Q

do thin or thick filaments change length during muscle contraction?

A

No the thick and thin layers begin to overlap.

27
Q

what happens when a muscle cells shortens

A

As a muscle cell shortens, the following events occur:
The I bands shorten
The distance between Z discs shortens
H bands disappear
Adjacent A bands move closer together (though their length does not change.)

28
Q

what is action potential

A

Neurons generate an electrical impulse that is conducted down the length of the axon; the electrical impulse

29
Q

At rest how is the neuron charged

A

negatively charged and the outside is positively charged.

30
Q

what is depolarization

A

it is the process of equalizing out the charges between the outside of the neuron and the neuron itself

31
Q

What makes the inside outside of neruron cells positive or negative?

A

the movement of ions

32
Q

what is a synapse?

A

a junction between two nerve cells, consisting of a minute gap across which impulses pass by diffusion of a neurotransmitter.

33
Q

what is the motor end plate

A

motor neuron establishes synaptic contact with a striated muscle fiber.

34
Q

what is the neuromuscular junction

A

the synapse/site of interaction between neuron & muscle cells – where neuron “meets” muscle fiber.

35
Q

what are thin filaments surrounded by

A

troponin and tropomyosin

36
Q

what are the two types of channels proteins that are responsible for action potential

A
  • Passive channels (leak channels) are always open (potassium channels)
  • Gated channels open and close in response to stimuli (sodium channels)
37
Q

what ion does the membrane let out more readily.

A

Potatsium

38
Q

where do all action potentials begin?

A

the brain sends an electrical signal down the axon to the muscle fibers and makes them contract

39
Q

what is troponin

A

a binding spot for calcium on the muscle cells

40
Q

what is tropmyosin

A

this is a organelle wall that moves and exposes the actin filaments when the troponin is unlocked

41
Q

what is cross bridge formation

A

when myosin heads can bind to actin

42
Q

what are the five steps of telling a muscle fiber to contract?

A

1: Action potential moves down motor neuron,
2: Neurotransmitter ACh is released into the synaptic cleft, it attaches to receptors on the sarcolemma
3: ACh binding triggers action potential in the muscle fiber being triggered.
4: Muscle Action Potential triggers Ca2+ release from the sarcoplasmic reticulum
5: Ca2+ initiates muscle contraction

43
Q

what is another way to say action potential

A

electrical curent

44
Q

what neruotransmitter signals the muscle cell?

A

Acetylcholine(ACh)

45
Q

what is the function of titin

A

the function of elastic filaments(titin) is to anchor thin filaments.

46
Q

what are the steps of bone reformation

A
  1. A Hematoma forms at the fracture site
  2. A soft callus of granulation tissue forms, regions begins to become vascularized.
  3. The soft callus is changed to bony callus, made of spongy bone. This takes about 2 months to complete.
  4. The bony callus is remodeled, excess material on diaphysis is removed, compact bone laid down to reconstruct shaft walls.
47
Q

what are the six types of synovial joint

A
Gliding joints
Hinge joints 
Pivot joints 
Ellipsoidal 
Saddle joints 
Ball and socket joints
48
Q

rigormortis

A

is a fixed muscular contraction that occurs shortly after death, when muscle cells run out of ATP. Myosin heads cannot release from actin filaments without ATP.

49
Q

what is a motor unit

A

a nueron and all the cells it is attached to

50
Q

what is sustained tension

A

Allows motor units to rest in rotation

51
Q

sustained tetnus

A

when every muscle fiber is contracted

52
Q

what is meant by isotonic contraction

A

the muscles actually shorten

53
Q

isometric contraction

A

the muscle stays the same length, tension is just built

54
Q

what are the five steps in the contraction cycle/ cross bridge cycling

A

Step 0: Ca2+ binding to troponin, to move tropomyosin, which allows the active sites of actin (thin filament) to be exposed.
Step 1: Activated myosin head is drawn to and is attached to the active site on myosin, forming a cross-bridge.
Step 2: The myosin head pivots, which causes the “power stroke” to be performed, pulling actin towards the M line.
Step 3: ATP binds to the myosin head, causing the cross bridge to detach
Step 4: Myosin head is reactivate/”re-cocked” into position (to move back to step 1).

55
Q

what is fine control compared to gross control in relation to a motor unit.

A

Fine control = 1-5 fibers (cells) per M.U. (eye)

Gross control= 1000’s of fibers (cells) per M.U. (leg)