Week 6 (heart failure) Flashcards
what is heart failure?
involves impaired cardiac pumping or filling
-associated with longstanding hypertension, Coronary artery disease, MI, DM, cig smoking, obesity and high cholesterol
what is heart failure characterized by?
- ventricle dysfunction
- reduced exercise tolerance
- diminished quality of life
- shortened life expectancy
what is the pathophysiology of heart failure?
-any alterations in the normal mechanisms regulating cardiac output (preload, afterload, myocardial contractility, heart rate, and metabolic state), of the individual can lead to ventricular dysfunction and may result in heart failure
is heart failure the same as congestive heart failure?
yes. now calling it diastolic or systolic heart failure
what is cardiac output?
heart rate X stroke volume (amount of blood ejected from ventricles each min)
what is normal cardiac output?
5 liters per min
what is the most common type of HF?
systolic heart failure
what does systolic heart failure result from?
the inability of the heart to pump blood
what occurs to the heart in systolic heart failure?
the left ventricle loses its ability to generate enough pressure to eject blood forward through the high-pressure aorta
-hallmark of systolic heart failure in a decrease in left ventricle ejection fraction (normal ejection fraction is greater than 55%)
what is ejection fraction?
percent of totally amount of blood in the left left ventricle that is ejected during each ventricular contraction (meaure EF by doing an echo)
what is normal ejection fraction?
55-65 % (grade 1)
what is a grade 3 (mild) ejection fraction?
40 - 55%
what is a grade 4 (severe) ejection fraction?
20 % or lower
what is diastolic heart failure?
- an impaired ability of the ventricles to fill during diastole
- decreased ventricle filling will result in decreased stroke volume thus high filling pressure in the pulmonary system
- predominantly affects women
what is diastolic heart failure often referred to as?
heart failure with preserved systolic function
what is the diagnosis of diastolic heart failure made on the presence of?
pulmonary congestion
what does diastolic heart failure usually the result of?
usually the result of left ventricle hypertrophy from chronic hypertension, aortic stenosis or hypertrophic cardiomyopathy
what are the main differences between systolic and diastolic heart failure?
systolic: difficulty ejecting heart out of ventricle
- less blood is pumped out of ventricles because weakened heart muscle cant squeeze the blood out as well
diastolic: decreased filling of ventricles.
- less blood fills the ventricles because the stiff heart cant relax normally
what is a mixed (systolic and diastolic) heart failure
seen in dilated cardiomyopathy
- a condition in which poor systolic function (weaking heart function) is further compromised by dilated left ventricular walls that are unable to relax
what is dilated cardiomyopathy?
- a condition in which poor systolic function (weaking heart function) is further compromised by dilated left ventricular walls that are unable to relax
- pts have poor ejection fraction (less thatn 35%)
- have high pulomary pressure and biventrical failure
- blood isnt getting ejected properly, so it back tracks into the lungs
what are some physiological characteristics of someone with dilated cardiomyopathy?
- pt will have low BP
- pt will have low Cardiac output
- poor renal perfusion (if cardiac output is lower than 35%, brain takes up 35% of the 02 blood, and renal needs 25%, so this is why it causes renal failure because there in not enough 02 blood for renal system)
- poor excersise tolerance and ventricular dysrhymias
what metaphor is used to explain dilated cardiomyopathy?
the elastic band metaphor: the more stretched out it gets, the less contractability (muscles of the heart get bigger, like a band - less contraction so cant push blood )
what are some compensatory mechanisms of the heart is attemp to try and maintain adequate cardiac output?
1) ventricular dilation (heart takes in more blood to try and get more out)
2) ventricular hypertrophy (heart tries to pump faster and stronger to get more blood out)
3) increased sympathetic nervous system stimulation (to try to get heart to work harder)
4) neurohormonal response (aldosteron system from kidneys)
what is dilation?
- its the enlargement of the chambers of the heart
- occurs when pressure in the left ventricles is elevated over a period of time
- the muscle fibers of the heart stretch in repsone to the volume of blood in the heart at then end of diastole (rubber band)
- the degree of stretch is directly related to the force of contraction in systole
- eventually the elastic elements of the muscle fibers are overstretched and can no longer contract effectively
what is hypertrophy?
- is an increase in the muscle mass and cardiac wall thickness in response to the overwork and strain of chronic heart failure
- occurs slowly
- hypertrophic heart muscles have poor contracility, poor coronart arety circulation and is pronce to venticular dysrhythmias
is hypertrophy inherited?
- is an inherited disorder
- these ppl will need heart transplants