Lower GI problems Flashcards
what is gastroenteritis
inflammation of the mucosa of the stomach and small intestine
manifestations include nausea, vomiting, diarrhea, abdominal cramping, and distension
-fever, increased WBC
-blood or mucous may present in stool
-most cases self limiting
-pt may be NPO until emesis is stopped
-if dehydration has occurred, IV replacement may be necessary
what is inflammatory bowel disease?
-an autoimmune disease that currently refers to two disorders of the GI tract
what are the two disease of inflammatory bowel disease
Crohns disease and ulcerative colitis
- both commonly occur during teen and adulthood
- both diseases can be debilitating
what is ulcerative colitis?
- Inflammation involves the mucosa ONLY
- The disease begins in the rectum and spreads proximally along the colon in a continuous fashion
- multiple abscesses develop in the intestinal glands
what happens as ulcerative colitis advances?
- as the disease advances, the abscesses break into the submucosa, leaving ulceration
- these ulcerations also destroy the mucosal epithelium, causing bleeding and diarrhea
what are some clinical manifestations of ulcerative colitis?
- abdominal pain and bloody diarrhea
- mild disease, diarrhea may consist of one or two semi formed stools containing small amounts of blood per day
- in severe cases, diarrhea is bloody, contains mucus and occurs 10-20 times a day
- in addition, fever and weight loss, anemia, tachycardia, and dehydration are present
complications of ulcerative colitis?
- toxic megacolon (extensive dilation and paralysis of colon)
- bleeding, and fulminant colitis are the most common complications
- perforation is most often associated with toxic megacolon by may occur alone
A patient who has had ulcerative colitis for more than 10 years has an increased risk for what?
colorectal cancer
-pt should be screened regularly with colonoscopy
Diagnostic tests for ulcerative colitis?
- colonoscopy with biopsy
- other tests which can supplement diagnosis (barium enema, fecal sample, complete blood count (CBC), C-reactive protein (CRP), sedimentation rate (ESR)
(blood test, electroylte tests, protein levels)
What will a CBC test show for ulcerative colitis?
-shows iron-deficiency anemia from blood loss through stool
what will other diagnostic tests for ulcerative colitis show?
- decreased sodium, potassium, chloride, bicarc, and magnesium are caused by fluid & electroyle losses from diarrhea
- hypoalbuminemia is present with severe disease and results from protein loss from bowel
why is a stool culture collected for diagnostic examination for ulcerative colitis?
-stool cultures should be obtained to rule out infectious causes of inflammation
what drug therapy is available for ulcerative colitis?
- Sulphasalazine is effective
- oral prednisone (effective in tx of mild to moderate disease without systemic manifestations)
what drug has been used in severe cases of ulcerative colitis when a pt failed wo respond to the usual drugs (before surgery is considered)
-immunosuppressive drugs (cyclosporine)
what surgical therapy is available for ulcerative colitis?
Approx 80-85% of pts go into remission with help of therapy
15-20% will require surgery
-surgery is indicated for when:
-the pt doesnt response to tx
-exacerbations are frequent and debilitating
-massive bleeding, strictures, or obstruction
-carcinoma develops