Diabetes Flashcards
what is diabetes mellitus?
Diabetes is a multisystem disease related to abnormal insulin production, impaired insulin utilization or both.
what is insulin?
a hormone produced by the B cells int he islets of Langerhans of the pancreas
- in continuously released in the bloodstream in small pulsatile increments with increased release when food is ingested
- normal glucose range is 4-gmmol/L
what is type 1 diabetes?
results from progressive destruction of pancreatic B cells
- manifestations develop when the persons pancreas can no longer produce insulin
- Cardinal symptoms include weight loss, polydipsia (excessive thirst), polyuria (frequent urination) and polyphagia (excessive hunger)
- these ppl will always need insulin
what type of ppl get diabetes type 1?
- most often occur in ppl who are younger than 30
- typically seen in ppl with a lean body type
what Is prediabetes?
- Prediabetes is when your blood glucose levels are too high, but not high enough to be called diabetes.
- is noted when a fasting or 2hr plasma glucose level is higher than normal (7.1-11mmol/L)
- ppl with prediabetes usually dont have symptoms
what might already be occurring in the body with a person who has prediabetes?
long term damage to the body, especially the heart and blood vessels, may already be occurring in patients with prediabetes
what can reduce the risk of developing actual diabetes with a person who has prediabetes?
- maintain a healthy weight
- exercising regularly- biggest thing to maintain blood sugar
- eating a healthy diet
- using medication when requires
- reduces chance of developing DM by 58%
what is type 2 diabetes?
- the pancreas usually continues to produce some insulin, but the insulin produced in insufficient for the needs of the body or is poorly utilized by the tissues or both
- muscle is unable to use glucose due to insulin resistance = increase blood glucose
- person may go for many years with undetected hyperglycemia
- disease onset is usually gradual
- usually diagnosed on routine labs
what charactericts present with a diagnosis of type 2 diabetes?
- occurs in ppl older than 35
- 80-90% are overweight at the time of diagnosis
- 3X higher in ppl with schizophrenia, this is presumably due to high sugars in the antipsychotics
What is gestational diabetes?
- develops during pregnancy
- detected between 24 and 28 weeks gestation
- nutritional counseling is considered to be the first line therapy
- if nutritional counselling alone does not achieve target fasting, or after-eating blood glucose levels or both, insulin therapy is usually indicated.
what test is used in determining glycemic control over time?
Hemoglobin A1C test
- works by showing the amount of blood glucose that has been attached to hemoglobin molecules, which are attached to the red blood cells for the life of the cell (120 days)
- A1C test indicated the overall glucose control for the previous 90-120 days
- normal range in 6% or less
what are the goals of Diabetes managment?
- promote well being
- reduce symptoms
- prevent acute complications of hyperglycemia and hypoglycemia
- delay the onset and progression of long-term complications
- nutritional therapy
- excersise
- self monitoring of blood glucose
- drug therapy
what are oral antihyperglycemic agents?
- are not insulin, but the work to improve the mechanism by which insulin and glucose are produced and used by the body
- primary action is to reduce glucose production by the liver
- does not promote weight gain
- for type 2, NOT type 1 (only use insulin)
what is the first line medication for most ppl with type 2? (that is a oral antihyperglycemic agent)
Metformin (Glucophage)
what is exogenous (injected) insulin always required for the managment of?
type 1 diabeties
what might insulin requirement increase during periods of?
severe stress, such as illness or surgery
what to insulins differ in regard to?
onset, peak action and duration
how many injections of insulin per day?
1-4 injections
what does exogenous (injected) insulin regime most closely mimics endogenous (body made) insulin?
basal-bolus regime, which uses rapid or short acting (bolus) insulin before meals and intermediate- or long acting (basal) background insulin once or twice a day
what is Lantus?
a 24 hours insulin with no peaks
what is the difference between basal and bolus insulin?
Basal insulin, also referred to as background insulin, regulates your glucose levels in between meals, and bolus insulin is extra insulin needed to manage your glucose levels after a meal.
what is mealtime insulin (bolus)
- synthetic rapid acting insulin
- onset is 10-15 min
- rapid-acting insulin is considered to be the type that best mimics natural insulin secretion in response to a meal
- should be administered 15 min BEFORE MEAL
benifits of bolus insulin?
- decreased post-meal hyperglycemia
- decreased hypoglycemic episodes
- increased flexibility compared to regular insulin
what is long acting insulin?
- glargine (lantus) is an extended long-acting basal insulin that are released steadily and continuously over 24 hours
- may be used in type 1 and type 2
- because the lack a peak action time, the risk for hyperglycemia is greatly
when might a diabetic patient be hypoglycemic?
pt will be hypoglycemia at peak of insulin if the dont eat
-always go back and check on pts after insulin administration and check their food tray for how much they ate
onset of rapid acting?
15 min
onset of short acting?
30min-1hr